Evidence map›Paper›PMID 40476179›Full record

ReviewMetabolism open2025

Metabolic regulation of Th17 and Treg cell balance by the mTOR signaling.

Zhengzheng Wang, Zhen Xu, Ming Zong, Lieying Fan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Metabolism open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Research Progress of Molecular HDrug design, development and therapy · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhengzheng WangSchool of Medicine, Tongji University, Shanghai, 200092, China.
Zhen XuSchool of Medicine, Tongji University, Shanghai, 200092, China.
Ming ZongDepartment of Clinical Laboratory, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
Lieying FanDepartment of Clinical Laboratory, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The balance between T helper type 17 (Th17) and regulatory T (Treg) cells is crucial for maintaining immune homeostasis. The breakdown of this equilibrium is strongly associated with autoimmune disorders, though the regulatory mechanism of the Th17/Treg plasticity is less well demonstrated. The glycolytic metabolism plays a vital role in regulating the Th17/Treg cell differentiation. The review addressed the importance of mammalian target of rapamycin (mTOR) signaling in the glycolysis pathway attributed to Th17/Treg cell balance and consequence. Notably, we discuss the consequences of its equilibrium that lead to various autoimmune diseases, which might provide a new insight into the potentially therapeutic drug target for autoimmune disorders.

Indexed as

Autoimmune disordersBalanceMetabolismmTORTh17Treg

Identifiers

PMID40476179
PMCPMC12140031

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.