Evidence map›Paper›PMID 40476173›Full record

ReviewInternational journal of cardiology. Heart & vasculature2025

The effect of national stress events on the incidence of Takotsubo syndrome.

Yuval Kahila, Maguli S Barel, Sharon Bruoha, Hadar Gadon, Efrat M Yeshurun Shemesh, Irina Lapidus, Karam Abd El Hay, Yuri Gluzman, Artyom Star, Chaim Yosefy and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of cardiology. Heart & vasculature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuval KahilaCardiology Department, Samson Assuta Ashdod Medical Center, Ashdod, Israel, and the Ben-Gurion University of the Negev, Israel.
Maguli S BarelCardiology Department, Hillel Yaffe Medical Center, Hadera, Israel, and the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel.
Sharon BruohaCardiology Department, Barzilai Medical Center, and The Ben-Gurion University of the Negev, Israel.
Hadar GadonCardiology Department, Samson Assuta Ashdod Medical Center, Ashdod, Israel, and the Ben-Gurion University of the Negev, Israel.
Efrat M Yeshurun ShemeshCardiology Department, Asaf Harofeh (Shamir) Medical Center, Beer Ya'acov, Israel.
Irina LapidusCardiology Department, Asaf Harofeh (Shamir) Medical Center, Beer Ya'acov, Israel.
Karam Abd El HayCardiology Department, Meir Medical Center, Kfar Saba, Israel.
Yuri GluzmanCardiology Department, Wolfson Medical Center, Holon, Israel.
Artyom StarCardiology Department, Soroka Medical Center, Beer Sheva, Israel.
Chaim YosefyCardiology Department, Barzilai Medical Center, and The Ben-Gurion University of the Negev, Israel.
Ronen RubinshteinCardiology Department, Wolfson Medical Center, Holon, Israel.
Abid AssaliCardiology Department, Meir Medical Center, Kfar Saba, Israel.
Moti HaimCardiology Department, Soroka Medical Center, Beer Sheva, Israel.
Shmuel FuchsCardiology Department, Asaf Harofeh (Shamir) Medical Center, Beer Ya'acov, Israel.
Eli I LevCardiology Department, Samson Assuta Ashdod Medical Center, Ashdod, Israel, and the Ben-Gurion University of the Negev, Israel.
Ariel RoguinCardiology Department, Hillel Yaffe Medical Center, Hadera, Israel, and the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to analyze whether national level stressful events were associated with an increase the incidence of Takotsubo syndrome. Takotsubo syndrome is an acute reversible heart failure, characterized by transient regional wall abnormality in the absence of a culprit coronary disease, usually caused by acute stressful etiologies. The terror attack of October 7th 2023 and the subsequent war had an enormous impact on the society in Israel. This was a multi-center, observational, analytic, retrospective, case-control study. To examine our hypothesis, we compared the incidence of Takotsubo syndrome in 7 medical centers in Israel during the period of October-December 2023 ("during war") to the period of October-December 2022 ("before war"), both as an absolute number and as a percentage of all admissions in these 7 medical centers. During the period before the war, 20 patients (0.54 % of all admissions to the cardiology departments) were hospitalized with a proven diagnosis of Takotsubo syndrome, compared with 39 patients (1.07 % of all admissions to the cardiology departments) during the war, accounting for a 95 % increase in the absolute number, and 98 % increase in the percentage of all admissions (p = 0.01, OR = 1.98). Most of the demographic and clinical characteristics, laboratory results, ECG, echocardiogram and angiographic findings were similar between the two groups. Our study showed a significant increase in the incidence of Takotsubo syndrome in Israel during the first three months of the war, suggesting the October 7th terror attack and the consequent war was a traumatic event for the society of Israel.

Indexed as

CardiomyopathyEmotional ReactionStressTakotsuboTerror

Identifiers

PMID40476173
PMCPMC12138397

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.