ReviewMedical journal of the Islamic Republic of Iran2024
The Effect of Oxytocin on Osteoporosis Improvement: A Systematic Review.
Review in Medical journal of the Islamic Republic of Iran, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Oxytocin: a neglected hormone in pituitary disease - From function to the diagnosis of a deficiency, resulting clinical relevance, and potential treatment options in endocrinology.Archives of endocrinology and metabolism · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoporosis, a chronic skeletal disorder leading to decreased bone density and increased fracture risk, predominantly affects postmenopausal women and the elderly. Current treatments have limitations due to long-term side effects, highlighting the need for new therapeutic approaches. Recent research suggests oxytocin (OT) may play a role in bone formation and density, providing a potential novel treatment avenue. Methods: This systematic review was conducted based on the PRISMA 2020 statement in 2023. PubMed, Scopus, Web of Science, and grey literature resources (ProQuest, and Google Scholar) were searched with oxytocin and osteoporosis keywords and their synonyms in the MeSH database without time limitation. Inclusion criteria encompassed experimental studies on humans and animals that examined the relationship between oxytocin and osteoporosis, with available full texts in English. The quality assessment of the studies was done based on the CAMARADES checklist, ARRIVE guideline, and NHLBI. Results: Out of 880 records, 30 studies met the inclusion criteria, comprising 19 animal studies and 11 human studies. The animal studies primarily indicated that oxytocin promotes bone formation, inhibits bone resorption, and may serve as a diagnostic marker for osteoporosis. Human studies showed a positive correlation between oxytocin levels and bone mineral density (BMD), particularly in postmenopausal women, suggesting oxytocin's protective role against osteoporosis. Conclusion: Oxytocin demonstrates anabolic effects on bone, enhancing bone regeneration and reducing resorption. The findings support oxytocin's potential as a treatment for osteoporosis, though clinical trials are necessary to confirm its efficacy and determine optimal dosing. Further research is needed to explore oxytocin's preventive role and effects on different populations.
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Registered trials
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