ArticleCureus2025
The Prevalence of Sarcopenia in Crohn's Disease Patients and Its Correlation With Disease Activity and Effect on Prognosis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and diagnostic variability of sarcopenia in India: A systematic review and meta-analysis.The Indian journal of medical research · 2026Pooled it
- Beyond Inflammation: Sarcopenia and Disease Phenotype Predict Unfavourable Course in Crohn's Disease-A Retrospective Observational Study.Biomedicines · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Crohn's disease (CD) is a chronic inflammatory disorder that can involve any part from mouth to anus but predominantly involves the distal small intestine and proximal colon. Sarcopenia is recognized as muscle failure consequent to loss of skeletal muscle strength, function, and mass. Sarcopenia was found to be prevalent in CD patients. Objectives The primary objective of our study was to assess the prevalence of sarcopenia in CD patients, its correlation with disease activity, and the effect of sarcopenia on the prognosis of CD. The secondary objectives were to find out whether there is any correlation of sarcopenia with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), albumin, and hemoglobin levels. Materials and methods This was a prospective cohort study done on 70 newly diagnosed CD patients in the Department of Gastroenterology, Government Medical College, Kozhikode, Kerala, India. Sarcopenia was assessed with the L3 skeletal muscle index (L3SMI) using a cross-sectional image at the L3 level from a cross-sectional image using Image J software. The cut-off of L3SMI was < 36.5 cm²/m² and 30.2 cm²/m² for male patients and female patients, respectively. The prevalence of sarcopenia was assessed. Its effect on clinical and endoscopic disease severity as well as blood parameters was assessed, and the outcome was measured by clinical remission, response to therapy, and number of disease flares. Results The study included 70 newly diagnosed CD patients above 18 years. Out of 70 patients, 26 were female patients and 44 were male patients. The mean age of the study population was 29.86. Mean L3SMI of the population was 37.35 ± 6.63 cm
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