ArticleCureus2025
Progressive Supranuclear Palsy: Clinical Features and Neuroimaging in a Case Series.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Progressive supranuclear palsy (PSP), a neurodegenerative disease with remarkable clinical diversity, lacks early and robust biomarkers to confirm the diagnosis in vivo. Given this, we analyzed magnetic resonance imaging studies in a series of patients admitted to a referral center after a comprehensive clinical examination. We had access to the complete clinical and radiologic data of 12 PSP patients. In all cases, initial symptoms included gait and speech abnormalities. A functional scale assessment was performed prior to visual assessment of neuroimaging studies and planimetric analysis. We found potentially useful neuroimaging-based indices derived from brainstem and ventricular measurements. When examining correlations between these indices and the most affected clinical domains of the disease, we observed that higher values in specific measurements involving the pons area and cerebellar peduncles were significantly correlated with more severe impairment in gait and speech in our case series.
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