Evidence map›Paper›PMID 40476090›Full record

ArticleThe journal of allergy and clinical immunology. Global2025

Predicting airway hyperresponsiveness to methacholine in patients with atopic dermatitis.

Ruth P Cusack, Anchalee Senavonge, Christiane E Whetstone, Nadia Alsaji, Karen J Howie, Caitlin Stevens, Jennifer Wattie, Lesley Wiltshire, Roma Sehmi, Paul M O'Byrne and 2 more

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Article in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ruth P CusackDivision of Respirology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Anchalee SenavongeDivision of Allergy, Immunology and Rheumatology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Christiane E WhetstoneDivision of Respirology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Nadia AlsajiDivision of Respirology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Karen J HowieDivision of Respirology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Caitlin StevensDivision of Respirology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Jennifer WattieDivision of Respirology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Lesley WiltshireDivision of Respirology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Roma SehmiDivision of Respirology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Paul M O'ByrneDivision of Respirology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Hermenio LimaDivision of Respirology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Gail M GauvreauDivision of Respirology, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There are overlapping physiologic mechanisms between atopic dermatitis (AD) and asthma. However, predictive factors in development of airway hyperresponsiveness (AHR) in patients with AD are lacking. Objective: This study aimed to determine factors predictive of AHR in patients with AD without a history of asthma. Methods: We performed a cross-sectional study measuring methacholine AHR in 12 participants with AD without a history of asthma. The clinical data measured included AD onset and severity. In addition, skin biopsy sample scores, sputum eosinophil counts, blood eosinophil counts, total IgE levels, and spirometry findings were obtained and compared between subjects with and without methacholine AHR. Results: Three of 12 participants with AD had a positive methacholine challenge result. Compared with the participants with AD without AHR, the participants with AD and AHR had significantly higher Eczema Area and Severity Index (EASI) scores (21.5 ± 13.6 vs 3.5 ± 2.9) and blood eosinophil counts (330/μL ± 50 vs 130/μL ± 60) (both Conclusion: In this small group study, our data show that patients with AD without asthma but with AHR have higher EASI scores, elevated eosinophil counts, and circulating IgE levels, along with lower values of FEV

Indexed as

airway hyperresponsivenessasthmaAtopic dermatitiseosinophils

Identifiers

PMID40476090
PMCPMC12139394

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.