ArticleInternational journal of clinical and health psychology : IJCHP
Neurobiological correlates of CBT response in OCD through the analysis of resting state networks.
Article in International journal of clinical and health psychology : IJCHP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Structural-functional multilayer brain network properties and outcome of combined repetitive transcranial magnetic stimulation and psychotherapy for obsessive-compulsive disorder.NeuroImage. Clinical · 2026Trial
- Neurofeedback interventions for obsessive-compulsive and related disorders: Current evidence and future directions.Journal of psychiatric research · 2026Review
- Burnout and the Brain-A Mechanistic Review of Magnetic Resonance Imaging (MRI) Studies.International journal of molecular sciences · 2025Review
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Authors and funding
9 authors.
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Abstract
Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by obsessions and compulsions that cause significant distress and functional impairment. Cognitive-behavioral therapy (CBT), particularly involving exposure and response prevention (ERP), is a first-line treatment for OCD, though patient response varies widely. This study investigates the neurobiological correlates of CBT response in OCD, focusing on resting-state functional connectivity (rsFC) alterations. Twenty-five patients with OCD and 26 matched controls underwent resting-state fMRI at baseline and post-CBT. Results indicated decreased rsFC at baseline in OCD patients compared to controls within the higher visual (HVN), posterior salience (PSN), and language networks (LN). Following CBT, patients showed increased HVN connectivity, suggesting a normalization of the rsFC within this network. Additionally, we found an association between baseline LN rsFC and symptom improvement after CBT (the higher the connectivity, the more the symptom improvement), suggesting that LN connectivity could be a predictor of treatment response. These findings emphasize the role of sensory processing networks in OCD and highlight the ability of CBT to modulate brain connectivity.
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