Evidence map›Paper›PMID 40476031›Full record

ArticleOpen forum infectious diseases2025

Ethylenediaminetetraacetic Acid Enhances Vancomycin and Reactive Oxygen Species-Mediated Killing of Vancomycin-Intermediate

Joshua Olson, Anuj K Khetarpal, Allen Jankeel, Arianna Lorenzana, Victor Nizet, George Sakoulas, Erlinda R Ulloa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joshua OlsonDepartment of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA.ORCID https://orcid.org/0000-0002-1733-0431
Anuj K KhetarpalDepartment of Pediatrics, University of California, Irvine School of Medicine, Irvine, California, USA.ORCID https://orcid.org/0009-0009-7344-8440
Allen JankeelDepartment of Pediatrics, University of California, Irvine School of Medicine, Irvine, California, USA.
Arianna LorenzanaDepartment of Pediatrics, University of California, Irvine School of Medicine, Irvine, California, USA.
Victor NizetDepartment of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA.ORCID https://orcid.org/0000-0003-3847-0422
George SakoulasDepartment of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA.ORCID https://orcid.org/0000-0002-6063-6217
Erlinda R UlloaDepartment of Pediatrics, University of California, Irvine School of Medicine, Irvine, California, USA.ORCID https://orcid.org/0000-0002-0330-278X

Funding

Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
Surprising Efficacy of Discounted Antibiotics vs. MDR Gram-Negative Pathogens Occurring Through Innate Immune SensitizationR01AI145310 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMARASWAMY, MONIKA, NIZET, VICTOR · 2020 to 2023
$1.9M
Beta-Lactamase Inhibitors Sensitize Multidrug-Resistant Gram-negative Pathogens to Innate Immune ClearanceK08AI151253 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI ULLOA, ERLINDA ROSE · 2020 to 2024
$1.0M
NCATS NIH HHS UM1 TR004927NIAID NIH HHS K08 AI151253NIAID NIH HHS R01 AI145310
6 · The paper itself

Abstract

Background: The emergence of antibiotic-tolerant staphylococcal strains, such as vancomycin-intermediate Methods: RNA sequencing analysis compared gene expression of a well-characterized VISA strain (D712) under physiological versus nutrient-rich conditions. Hydrogen peroxide (H Results: VISA exhibited downregulation of Krebs cycle enzymes and other genes associated with resistance to iron and ROS-mediated killing under physiological conditions. EDTA, alone or with vancomycin, improved H Conclusions: EDTA potentiates vancomycin efficacy against VISA in vivo and enhances susceptibility to H

Indexed as

antibiotic toleranceEDTAROSvancomycinVISA

Identifiers

PMID40476031
PMCPMC12138334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.