Evidence map›Paper›PMID 40476029›Full record

ArticleOpen forum infectious diseases2025

Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations.

Jesse D Sutton, Jae Hyoung Lee, Karen Howard, Katelyn S Quartuccio, Christopher McCoy, Alok Gupta, Judianne C Slish, Drew W Engers, Anurag N Malani, Sara M Karaba and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jesse D SuttonDepartment of Pharmacy, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-1476-1746
Jae Hyoung LeeDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Karen HowardDepartment of Pharmacy, University of Utah Health, Salt Lake City, Utah, USA.
Katelyn S QuartuccioDepartment of Pharmacy, University of Rochester Medical Center-Highland Hospital, Rochester, New York, USA.ORCID https://orcid.org/0000-0002-6658-9132
Christopher McCoyBeth Israel Lahey Health Pharmacy, Boston, Massachusetts, USA.
Alok GuptaDivision of Infectious Diseases, Department of Medicine, University of Rochester Medical Center-Highland Hospital, Rochester, New York, USA.
Judianne C SlishDepartment of Pharmacy, University of Rochester Medical Center-Highland Hospital, Rochester, New York, USA.
Drew W EngersDivision of Infectious Diseases, Department of Internal Medicine, Trinity Health Ann Arbor, Ann Arbor, Michigan, USA.
Anurag N MalaniDivision of Infectious Diseases, Department of Internal Medicine, Trinity Health Ann Arbor, Ann Arbor, Michigan, USA.
Sara M KarabaDivision of Infectious Diseases, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-8452-5549
Kelly E PillingerPRIME Education, New York, New York, USA.ORCID https://orcid.org/0000-0003-2697-886X
Pranita D TammaDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-4143-6324
Timothy C JenkinsDivision of Infectious Diseases, Department of Medicine, Denver Health, Denver, Colorado, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data on treatment durations for gram-negative bloodstream infections in clinical practice are limited. In this study of 4240 gram-negative bloodstream infection episodes during 2019 from 24 US hospitals, the median duration of therapy was 12 days (IQR, 9-15); 59% were treated for >10 days. There was marked variability in treatment durations across hospitals.

Indexed as

antimicrobial stewardshipantimicrobial treatmentduration of therapygram-negative bacteremiagram-negative bloodstream infection

Identifiers

PMID40476029
PMCPMC12138504

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.