ArticleFrontiers in endocrinology2025
Association of self-reported sleep duration with leukocyte telomere length in type 2 diabetes mellitus patients.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Leukocyte telomere length (LTL) is a biomarker of aging, and sleep duration is associated with LTL. However, research exploring the relationship between sleep duration and LTL has yielded inconsistent results. This study aimed to investigate the association between sleep duration and LTL in Chinese patients with type 2 diabetes mellitus (T2DM). Methods: A cross-sectional study involving 1,027 T2DM patients was conducted in Ningxia Province, China. Sleep duration was assessed through self-reported measures, while leukocyte telomere length (LTL) was determined using a quantitative polymerase chain reaction (q-PCR) method. Restricted cubic splines (RCS) analysis was initially performed to evaluate the potential nonlinear relationship between sleep duration and LTL. Subsequently, a multiple mixed-effect linear regression model was utilized to examine this association. Results: Binary analysis revealed an inverse association between sleep duration and LTL (β=-0.170, 95% Conclusion: This study adds to the growing literature relating sleep duration with biomarkers of aging and suggests that the shortening of LTL may reflect potential mechanisms through which longer sleep duration contributes to pathological conditions in T2DM patients. It is recommended that healthcare providers, health promoters, and patients pay greater attention to sleep habits, avoiding excessively long sleep durations, to potentially slow cellular aging.
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