Evidence map›Paper›PMID 40475958›Full record

ArticleFrontiers in medicine2025

Toll interacting protein gene polymorphisms in patients with systemic sclerosis: association with interstitial lung disease, outcome, and survival.

Niels Schröder, Jitka Andrä, Diana Knuth-Rehr, Silke Leja, Nicolas Hunzelmann, Pia Moinzadeh, Konrad Frank, Eda Börner, Francesco Bonella

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Interstitial lung disease and the STING pathway.The Journal of clinical investigation · 2026
    Review
  3. Frontiers in medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Niels SchröderCenter for Interstitial and Rare Lung Diseases, Ruhrlandklinik, Pneumonology Department, University of Duisburg-Essen, Essen, Germany.
Jitka AndräCenter for Interstitial and Rare Lung Diseases, Ruhrlandklinik, Pneumonology Department, University of Duisburg-Essen, Essen, Germany.
Diana Knuth-RehrDepartment of Dermatology and Venereology, University Hospital Cologne, Cologne, Germany.
Silke LejaDepartment of Dermatology and Venereology, University Hospital Cologne, Cologne, Germany.
Nicolas HunzelmannDepartment of Dermatology and Venereology, University Hospital Cologne, Cologne, Germany.
Pia MoinzadehDepartment of Dermatology and Venereology, University Hospital Cologne, Cologne, Germany.
Konrad FrankDepartment III of Internal Medicine, Section Pneumology, University Hospital Cologne, Cologne, Germany.
Eda BörnerCenter for Interstitial and Rare Lung Diseases, Ruhrlandklinik, Pneumonology Department, University of Duisburg-Essen, Essen, Germany.
Francesco BonellaCenter for Interstitial and Rare Lung Diseases, Ruhrlandklinik, Pneumonology Department, University of Duisburg-Essen, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pulmonary fibrosis is a leading cause of death in patients with Systemic sclerosis (SSc). Single nucleotide polymorphisms (SNPs) within Toll interacting protein ( Patients and methods: 106 consecutive SSc patients (77 female) with ( Results: The Conclusion:

Indexed as

genetic variantsILDoutcomesystemic sclerosisTOLLIP

Identifiers

PMID40475958
PMCPMC12137070

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.