ArticleFrontiers in psychiatry2025
Genetic predisposition to digital device use and the risk of five psychiatric disorders.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Psychiatric disorders were observationally related to digital device use, but causality and direction remained unclear. We aimed to uncover the causal links between digital device use and five psychiatric disorders risk utilizing the two-sample Mendelian Randomization method. Methods: We obtained genetic variants related to digital device use from the UK Biobank's genome-wide association study and psychiatric disorders data from the Psychiatric Genomics Consortium. The primary analysis employed the inverse-variance weighted method, complemented by sensitivity analyses to determine heterogeneity and pleiotropy. Results: There were causal relationships between genetically increased mobile phone use [odds ratio (OR) = 1.75, 95% confidence interval (CI): 1.31-2.33], more television watching (OR = 3.39, 95% CI: 2.64-4.35) and a higher risk of attention-deficit/hyperactivity disorder (ADHD). Genetically determined duration of computer use was also causally related to the risk of autism spectrum disorder (ASD) (OR = 2.66, 95%CI: 1.82-3.88). Conversely, ADHD was significantly positively associated with playing computer games ( Conclusions: Our findings indicate potential causal links between genetic disposition to use digital devices and psychiatric disorders, such as ADHD, ASD, and MDD, highlighting the importance of digital device use in both prevention and management of these disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.