Evidence map›Paper›PMID 40475915›Full record

ArticleJournal of bone oncology2025

Analysis of skeletal pain, general symptoms and patient-reported outcome measures and their value in detecting symptomatic progression - An interdisciplinary prospective study in patients with multiple myeloma.

Carlotta Pietsch, Monika Engelhardt, Gabriele Ihorst, Laura Wystrach, Johannes Jung, Hagen Schmal, Andreas Frodl, Ralph Wäsch, Evangelos Terpos, Georg W Herget

Abstract read
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In one paragraph

Article in Journal of bone oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carlotta PietschDepartment of Orthopedics and Trauma Surgery, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Monika EngelhardtComprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Gabriele IhorstClinical Trials Unit, Medical Clinic, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Laura WystrachDepartment of Orthopedics and Traumatology, Agaplesion Elisabethenstift, Darmstadt, Germany.
Johannes JungDepartment of Internal Medicine III, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
Hagen SchmalDepartment of Orthopedics and Trauma Surgery, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Andreas FrodlDepartment of Orthopedics and Trauma Surgery, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Ralph WäschComprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Evangelos TerposDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Georg W HergetDepartment of Orthopedics and Trauma Surgery, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delayed diagnosis of multiple myeloma (MM) and progressive disease (PD) can both increase the risk of skeletal complications and do affects patients' quality of life (QoL). In this prospective study we analyzed skeletal pain, general symptoms and patient-reported outcome measures (PROMs) in patients with MM and their value in detecting symptomatic progression. We evaluated 502 patients, 47 with initial diagnosis (ID) of MM and 455 follow-up patients. At ID, 74% reported bone pain, mostly in the spine. General symptoms, particularly fatigue, were present in 89% of the patients. 88/455 (19%) of the follow-up patients experienced PD. Of these, 65% reported skeletal pain and 81% exhibited general symptoms, with fatigue being the most common. PD was suspected and confirmed as the cause of clinical symptoms in 59/88 (67%) and not suspected in 29/88 (33%). Occurrence and character of bone pain and general symptoms differed significantly between patients with and without PD, as did QoL and health-related status. Logistic regression analysis demonstrated that bone pain at night, pain in various locations, pain of known character with occurrence in different location, pain in the chest, pelvis, and thigh as well as fatigue and weight loss were associated with an increased risk of PD. In conclusion, bone pain and general symptoms are helpful in identifying both MM and PD. PROMs can aid in the diagnosis of PD through symptom-based patient assessment. Serologic and, especially in the case of skeletal complaints, additional radiologic diagnostics are required to confirm suspected and to detect unexpected PD.

Indexed as

Clinical warning signsEarly detection of cancerGeneral symptomsMultiple myelomaPROMsSkeletal pain

Identifiers

PMID40475915
PMCPMC12138919

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.