ArticleiScience2025
Exploring the role of the vaginal microbiome in HPV infection dynamics: A prospective cohort study.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Persistence of Bacterial Dysbiosis, Cervicovaginal Human Papillomaviruses, and Inflammation in Women Living With HIV-1 After a Year of Antiretroviral Therapy.The Journal of infectious diseases · 2026Observational
- Vaginal Microecological Imbalance, Human Papillomavirus Infection, and Cervical Carcinogenesis: Mechanisms and Clinical Implications.International journal of general medicine · 2026Review
- Vaginal microecological diversity and Ureaplasma urealyticum co-infection in high-risk HPV infection: a cross-sectional study.Frontiers in cellular and infection microbiology · 2026Article
- Identification of key vaginal microbial signatures and immune remodeling associated with HR-HPV clearance following Kushen Gel treatment: a longitudinal analysis.Frontiers in medicine · 2026Article
- Investigating the correlation between oncogenic HPV, sexually transmitted disease, and vaginal microbiota in patients with normal Pap smear.Iranian journal of microbiology · 2025Article
- Cervicovaginal Microbiome: Physiology, Age-Related Changes, and Protective Role Against Human Papillomavirus Infection.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent human papillomavirus (HPV) infection is a key risk factor for cervical cancer, often associated with changes in the vaginal microbiome (VMB). High-throughput 16S rRNA sequencing was used to study the VMB in a prospective cohort of 731 individuals. Participants were monitored through two follow-up screenings and then categorized into two groups: 22 female patients with persistent HPV infection (PHI), 31 female patients who cleared the infection (HC). After excluding those with HPV and other urogenital infections, 43 female patients were selected as controls, and their samples were analyzed using the same high-throughput sequencing method. Results indicate that high-risk HPV infections correlate with increased microbial diversity and reduced Lactobacillus levels. Even after HPV clearance, distinct microbial differences persist, suggesting that VMB could serve as a biomarker for monitoring infection and cervical health management, especially in populations at higher risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.