Evidence map›Paper›PMID 40475779›Full record

ArticleFrontiers in immunology2025

Immunomodulatory effects of alpha vs beta radiopharmaceutical therapy in murine prostate cancer.

Carolina A Ferreira, Hemanth K Potluri, Mojdeh Mahmoudian, Christopher F Massey, Joseph J Grudzinski, Amanda M Carston, Nathan B Clemons, Malick Bio Idrissou, Anna S Thickens, Zachary T Rosenkrans and 10 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Enhanced Antitumor Efficacy ofInternational journal of radiation oncology, biology, physics · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. LiposomalCancer science · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Carolina A FerreiraDepartments of Radiology, Pharmacology and Toxicology and Biomedical Engineering, Michigan State University, East Lansing, MI, United States.
Hemanth K PotluriDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Mojdeh MahmoudianDepartment of Cell and Molecular Biology, Michigan State University, East Lansing, MI, United States.
Christopher F MasseyDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, WI, United States.
Joseph J GrudzinskiDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, WI, United States.
Amanda M CarstonDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, WI, United States.
Nathan B ClemonsDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, WI, United States.
Malick Bio IdrissouDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, WI, United States.
Anna S ThickensDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, WI, United States.
Zachary T RosenkransDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, WI, United States.
Cynthia ChoiPharmaceutical Sciences Program, University of Wisconsin-Madison, Madison, WI, United States.
Caroline P KerrDepartment of Human Oncology, University of Wisconsin-Madison, Madison, WI, United States.
Anatoly N PinchukDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, WI, United States.
Ohyun KwonDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, WI, United States.
Justin J JefferyCarbone Cancer Center, University of Wisconsin-Madison, Madison, WI, United States.
Bryan P BednarzDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, WI, United States.
Zachary S MorrisDepartment of Human Oncology, University of Wisconsin-Madison, Madison, WI, United States.
Jamey P WeichertDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Douglas G McNeelDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Reinier HernandezDepartments of Medical Physics and Radiology, University of Wisconsin-Madison, Madison, WI, United States.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Radionuclide Production and Radiochemistry Core Description CoreP01CA250972 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI MORRIS, ZACHARY SCOTT, WEICHERT, JAMEY P · 2020 to 2024
$12.5M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Targeted radionuclide therapy for tumor immunomodulation and enhancing immunotherapy responseF30CA268780 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KERR, CAROLINE PAULA ANNE · 2022 to 2025
$145k
NCI NIH HHS F30 CA268780NCI NIH HHS P01 CA250972NCI NIH HHS P30 CA014520NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

Background: Radiation therapy can modulate the tumor microenvironment (TME), influencing antitumor immune responses. This study compared the immunomodulatory effects of alpha-emitting ( Methods: We assessed immunological changes in TRAMP-C1 and Myc-CaP tumor models treated with Results: In general, Conclusion: Alpha-emitting

Indexed as

ActiniumAlpha ParticlesBeta ParticlesImmunomodulationProstatic NeoplasmsRadioisotopesRadiopharmaceuticalsAnimalsCell Line, TumorCytokinesDisease Models, AnimalHumansLutetiumMaleMiceMice, Inbred C57BLActiniumCytokinesLutetiumLutetium-177RadioisotopesRadiopharmaceuticalsimmunomodulationprostate cancerradionuclidesradiopharmaceutical therapytargeted alpha therapytumor microenvironment

Identifiers

PMID40475779
PMCPMC12137342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.