Evidence map›Paper›PMID 40475766›Full record

ReviewFrontiers in immunology2025

A case report of small cell neuroendocrine carcinoma of the ovary and review of the literature.

Ying Zhao, Fuli Kang, Xiangshu Kong, Ning Wang

Abstract readCase ReportsReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ying ZhaoDepartment of Gynecology and Obstetrics, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Fuli KangDepartment of Gynecology and Obstetrics, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Xiangshu KongDepartment of Gynecology and Obstetrics, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Ning WangDepartment of Gynecology and Obstetrics, Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small cell neuroendocrine carcinoma of the ovary is rare pathological type with an undefined mechanism, low incidence, but high metastatic rate, high aggressiveness, and very poor prognosis, and there are no standardized treatment protocols or guidelines. In this article, we report a 48-year-old woman diagnosed with small cell neuroendocrine carcinoma of the ovary after puncture biopsy of a pelvic mass, who underwent 8 cycles of paclitaxel+carboplatin regimen chemotherapy (with the addition of the anti-angiogenesis targeted agent bevacizumab in the first 2 times, and the immunosuppressant tirilizumab in the last 2 times), followed by 12 times of tirilizumab monotherapy maintenance therapy, which was highly effective. It is believed that with newer technologies, the use of surgery, chemotherapy combined with immunotherapy, targeted therapy, genetic testing and construction of animal tumor models will play a key role in the treatment and monitoring of the prognosis of this rare disease.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, NeuroendocrineCarcinoma, Small CellOvarian NeoplasmsCarboplatinFemaleHumansMiddle AgedTreatment OutcomeCarboplatinchemotherapyimmunotherapymalignant tumor of ovarysmall cell neuroendocrine carcinomatargeted therapy

Identifiers

PMID40475766
PMCPMC12137309

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.