ArticleReviews in cardiovascular medicine2025
Relationship Between Carotid Intraplaque Neovascularization and Immune-Inflammatory Biomarkers with Coronary Stenosis.
Article in Reviews in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Intraplaque neovascularization (IPN) correlates significantly with plaque vulnerability and can be detected using Angio PLanewave UltraSensitive imaging technology (Angio PL.U.S.; AP). Several immune-inflammatory biomarkers that reflect the state of inflammation and immune homeostasis in the body are currently used to assess cardiovascular and cerebrovascular diseases. This study aimed to investigate the correlation between carotid IPN scores and several immune-inflammatory indicators in patients with different degrees of coronary artery stenosis. Methods: This study prospectively enrolled 107 patients with coronary artery stenosis confirmed by coronary angiography (CAG). Preoperative ultrasonography was performed to screen for carotid plaques, and AP was conducted to determine whether IPN was present and correctly scored. The levels of immune-inflammatory indicators, plaques, and coronary artery lesions between groups with and without IPN and different IPN scores were analyzed. We utilized logistic regression models to determine the independent predictors of IPN and constructed receiver operating characteristic (ROC) curves. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: Differences in systemic immune inflammation index (SII) levels and plaque thicknesses were found between the groups with and without IPN and between different IPN scores ( Conclusion: Elevated SII levels and increased plaque thickness were associated with the vulnerability of carotid plaques in patients with coronary artery stenosis and may signal increased coronary artery stenosis. The Clinical Trial Registration: ChiCTR2400094458, https://www.chictr.org.cn/hvshowprojectEN.html?id=266292&v=1.0.
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