ArticleReviews in cardiovascular medicine2025
Metabolic Status and Atrioventricular Block Risk: The Role of Physical Activity.
Article in Reviews in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lean body mass is the independent and predominant anthropometric variable associated with atrioventricular block.Heart rhythm O2 · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The relationship between metabolic status as a possible risk factor and predictor of response to moderate-to-vigorous physical activity (MVPA) in atrioventricular block (AVB) remains unclear. Methods: A total of 82,365 UK Biobank participants without a history of AVB or pacemaker implantation, and who were involved in accelerometer work-up, were chosen for the study population. Metabolic status was classified into two categories, healthy and unhealthy, using modified criteria for metabolic syndrome from the International Diabetes Federation. We used the multivariable Cox proportional model to assess the associations between metabolic status and primary outcome (composite of second-degree AVB or third-degree AVB) or secondary outcomes (each component in the primary outcome and AVB-related pacemaker implantation). The relationship between MVPA min/week and the primary outcome in each metabolic status category was assessed using restricted cubic splines. Results: Of the 82,365 participants, the mean age was 62.3 years, and 44.1% were men. In total, 299 primary outcome events occurred during the 6.1-year follow-up. Compared to metabolically healthy participants, metabolically unhealthy participants had a 58% higher risk of the primary outcome (hazard ratio (HR): 1.58, 95% confidence interval (CI): 1.25-2.00; Conclusions: Generally, in the middle-aged population, metabolically unhealthy participants had a statistically significantly higher risk of second- or third-degree AVB and AVB-related pacemaker implantation than metabolically healthy participants. However, MVPA reduced the risk of second- or third-degree AVB in the metabolically unhealthy participants, though the effect was attenuated with excessive MVPA. From this perspective, identifying and encouraging exercise in metabolically unhealthy individuals is essential. Due to its observational nature, future research should verify the preventive effects of increased MVPA on conduction block in populations with metabolic abnormalities through randomized controlled trials. Moreover, the biological mechanisms and safety of the protective effects of excessive MVPA require further verification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.