Evidence map›Paper›PMID 40475700›Full record

ArticleNeurophotonics2025

Cerebrovascular alterations in a mouse model of late-onset Alzheimer's disease.

Christian Crouzet, Danny F Xie, Maiella Nona Laquindanum Nuqui, Jonathan Hasselman, Thinh Phan, Robert H Wilson, David Baglietto-Vargas, Celia Da Cunha, Hayk Davtyan, Stefania Forner and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Christian CrouzetUniversity of California, Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.ORCID https://orcid.org/0000-0002-8809-2119
Danny F XieUniversity of California, Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Maiella Nona Laquindanum NuquiUniversity of California, Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.ORCID https://orcid.org/0009-0006-8925-6708
Jonathan HasselmanUniversity of California, Irvine, Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, California, United States.
Thinh PhanUniversity of California, Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.ORCID https://orcid.org/0000-0002-1210-6000
Robert H WilsonUniversity of Dayton, Department of Physics, Dayton, Ohio, United States.ORCID https://orcid.org/0000-0002-9067-3051
David Baglietto-VargasUniversidad de Málaga, Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Facultad de Ciencias, Departamento Biologia Celular, Genetica y Fisiologia, Malaga, Spain.ORCID https://orcid.org/0000-0003-1441-3175
Celia Da CunhaUniversity of California, Irvine, Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, California, United States.
Hayk DavtyanUniversity of California, Irvine, Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, California, United States.ORCID https://orcid.org/0000-0001-8554-6456
Stefania FornerUniversity of California, Irvine, Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, California, United States.
Amandine JullienneUniversity of California, Riverside, School of Medicine, Division of Biomedical Sciences, Riverside, California, United States.ORCID https://orcid.org/0000-0001-9458-055X
Afsheen BazrafkanUniversity of California, Irvine, Department of Neurology, Irvine, California, United States.
Frank M LaFerlaUniversity of California, Irvine, Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, California, United States.
Andre ObenausUniversity of California, Riverside, School of Medicine, Division of Biomedical Sciences, Riverside, California, United States.
Mathew Blurton-JonesUniversity of California, Irvine, Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, California, United States.
Yama AkbariUniversity of California, Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
Kim N GreenUniversity of California, Irvine, Institute for Memory Impairments and Neurological Disorders (UCI MIND), Irvine, California, United States.
Bernard ChoiUniversity of California, Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.ORCID https://orcid.org/0000-0002-4380-8291

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI FRANK M LAFERLA · 2017 to 2026
$71.9M
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
NRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2M
Acquisition of nonlinear optical microscopy platform for advanced tissue imagingS10OD028698 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI POTMA, ERIC OLAF · 2020 to 2020
$1.6M
Multimodal Optical Imaging of Hyperdynamic Cerebral Responses to Cardiac Arrest and ResuscitationR21EB024793 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI AKBARI, YAMA · 2017 to 2019
$925k
High-Throughput DNA SequencerS10OD021718 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2016 to 2016
$600k
PacBio RS Single Molecule, Real-Time (SMRT) DNA SequencerS10OD010794 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2012 to 2012
$600k
Multiscale optical characterization of cerebrovascular structure, function and oxygen utilization in a novel mouse model of sporadic Alzheimer's diseaseR21AG066000 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHOI, BERNARD · 2020 to 2020
$411k
NCATS NIH HHS TL1 TR001415NCATS NIH HHS UM1 TR004927NCI NIH HHS P30 CA062203NIAMS NIH HHS P30 AR075047NIA NIH HHS R21 AG066000NIA NIH HHS T32 AG000096NIA NIH HHS U54 AG054349NIBIB NIH HHS R21 EB024793NIH HHS S10 OD010794NIH HHS S10 OD021718NIH HHS S10 OD028698
6 · The paper itself

Abstract

Significance: Alzheimer's disease (AD) is an age-related neurodegenerative disorder with cerebrovascular alterations contributing to cognitive decline. Assessing cerebrovascular changes in mouse models that mimic the human condition of late-onset, sporadic AD is important for better human applicability. Aim: To assess cerebrovascular changes in three mouse models: (1) 3xTg-AD; (2) the humanized amyloid-beta knock-in ( Approach: We measured resting-state cerebral blood flow (CBF) and neurovascular coupling (NVC) using laser speckle imaging (LSI) and performed Results: Our study identifies specific cerebrovascular alterations in the Conclusions: Our findings demonstrate that the

Indexed as

Alzheimer’s diseasecerebral blood flowlaser speckle contrast imagingmicroscopyneurovascular couplingRNA sequencing

Identifiers

PMID40475700
PMCPMC12138534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.