Evidence map›Paper›PMID 40475682›Full record

ArticlebioRxiv : the preprint server for biology2025

Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage.

Sarah L Guest, Katrina B Velle, Samantha M Jacques, Yvette Park, Jarrett Man, Margaret A Titus, Lillian K Fritz-Laylin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sarah L GuestUniversity of Massachusetts Amherst, Department of Biology, Amherst MA 01003.ORCID 0000-0001-9020-2631
Katrina B VelleUniversity of Massachusetts Dartmouth, Biology Department, Dartmouth MA 02747.ORCID 0000-0002-9985-9522
Samantha M JacquesUniversity of Massachusetts Dartmouth, Biology Department, Dartmouth MA 02747.
Yvette ParkUniversity of Massachusetts Amherst, Department of Biology, Amherst MA 01003.
Jarrett ManUniversity of Massachusetts Amherst, Department of Biology, Amherst MA 01003.ORCID 0000-0002-6412-8607
Margaret A TitusUniversity of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis MN, 55455.
Lillian K Fritz-LaylinHoward Hughes Medical Institute and the Department of Biology, University of Massachusetts, Amherst, MA, 01003.ORCID 0000-0002-9237-9403

Funding

Mechanism of myosin motor-dependent filopodia formationR01GM122917 · NIGMS · UNIVERSITY OF MINNESOTA · PI TITUS, MARGARET A · 2017 to 2024
$3.2M
Chytrid fungi and the functional specification of actin networksR35GM143039 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI FRITZ-LAYLIN, LILLIAN KATHLEEN · 2021 to 2025
$1.9M
Defining cytoskeletal mechanisms driving cell motility in NaegleriaR00GM147656 · NIGMS · UNIVERSITY OF MASSACHUSETTS DARTMOUTH · PI Katrina Velle · 2024 to 2026
$747k
NIGMS NIH HHS R00 GM147656NIGMS NIH HHS R01 GM122917NIGMS NIH HHS R35 GM143039
6 · The paper itself

Abstract

Myosin 2-dependent actin contractility drives essential cell functions including fast crawling motility in animal cells,

Identifiers

PMID40475682
PMCPMC12139777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.