Evidence map›Paper›PMID 40475681›Full record

ArticlebioRxiv : the preprint server for biology2025

Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo.

Malay Mondal, Windfield S Swetman, Shazeed-Ul Karim, Sabin Shrestha, Ashe M Davis, Fengwei Bai, Faqing Huang, Tristan D Clemons, Vijayaraghavan Rangachari

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Malay MondalDepartment of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.ORCID 0009-0001-9359-4199
Windfield S SwetmanSchool of Polymer Science and Engineering, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.ORCID 0009-0005-3534-3147
Shazeed-Ul KarimDepartment of Cell and Molecular Biology, School of Biological, Environmental, and Earth Sciences, University of Southern Mississippi, Hattiesburg, MS 39406, USA.ORCID 0009-0002-8980-2183
Sabin ShresthaDepartment of Cell and Molecular Biology, School of Biological, Environmental, and Earth Sciences, University of Southern Mississippi, Hattiesburg, MS 39406, USA.
Ashe M DavisSchool of Polymer Science and Engineering, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.
Fengwei BaiDepartment of Cell and Molecular Biology, School of Biological, Environmental, and Earth Sciences, University of Southern Mississippi, Hattiesburg, MS 39406, USA.ORCID 0000-0002-9170-2475
Faqing HuangDepartment of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.ORCID 0000-0001-8185-7097
Tristan D ClemonsSchool of Polymer Science and Engineering, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.ORCID 0000-0001-8042-0141
Vijayaraghavan RangachariDepartment of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, MS, 39406, USA.ORCID 0000-0002-0085-9777

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Biology the initiator: Harnessing Reactive Oxygen Species for Biocompatible PolymerizationR21EB033533 · NIBIB · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI CLEMONS, TRISTAN · 2023 to 2025
$592k
NIBIB NIH HHS R21 EB033533NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

Biomolecular condensates (BCs) are phase-separated viscoelastic hubs within demixed solutions enriched in proteins and nucleic acids. Such condensates, also called membraneless organelles, are increasingly observed in cells and serve as transient hubs for spatial organization and compartmentalization of biomolecules. Along with the transiency of formation and dissolution, their ability to sequester molecules has inspired us to develop BCs as potential vehicles to transport and deliver molecular cargo. We recently reported the design of disulfide bond cross-linked phase-separating peptide (PSP) condensates that spontaneously dissolve in reducing conditions (

Identifiers

PMID40475681
PMCPMC12139793

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.