Evidence map›Paper›PMID 40475624›Full record

ArticlebioRxiv : the preprint server for biology2025

Tuning the interaction of a ParA-type ATPase with its partner separates bacterial organelle positioning from partitioning.

Jordan A Byrne, Hema M Swasthi, Longhua Hu, Christopher A Azaldegui, Jian Liu, Anthony G Vecchiarelli

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jordan A ByrneDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Hema M SwasthiDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Longhua HuDepartment of Cell Biology & Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christopher A AzaldeguiProgram in Chemical Biology, University of Michigan, Ann Arbor, MI, USA.
Jian LiuDepartment of Cell Biology & Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anthony G VecchiarelliDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-6198-3245

Funding

Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
Predictive multi-scale model of focal adhesion-based durotaxisR01GM148459 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Jian Liu · 2023 to 2026
$1.6M
Coordinated Spatial Organization in BacteriaR35GM152128 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Anthony G Vecchiarelli · 2024 to 2026
$1.1M
NIGMS NIH HHS R01 GM148459NIGMS NIH HHS R35 GM152128NIGMS NIH HHS T32 GM145304
6 · The paper itself

Abstract

The maintenance of carboxysome distribution (Mcd) system comprises the proteins McdA and McdB, which spatially organize carboxysomes to promote efficient carbon fixation and ensure their equal inheritance during cell division. McdA, a member of the ParA/MinD family of ATPases, forms dynamic gradients on the nucleoid that position McdB-bound carboxysomes. McdB belongs to a widespread but poorly characterized class of ParA/MinD partner proteins, and the molecular basis of its interaction with McdA remains unclear. Here, we demonstrate that the N-terminal 20 residues of

Indexed as

Bacterial MicrocompartmentsCarboxysomeMcdA ATPaseMcdAB systemMolecular Positioning SystemSpatial organizationSubcellular Organization

Identifiers

PMID40475624
PMCPMC12139897

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.