Evidence map›Paper›PMID 40475607›Full record

ArticlebioRxiv : the preprint server for biology2025

Cytoplasmic CaMKIIδ-B prevents myocardial recovery in heart failure.

Thomas G Martin, Dakota R Hunt, Christopher C Ebmeier, Abhishek P Dhand, Christina Alamana, Joseph C Cleveland, Sharon L Graw, Sarah Bruner, Michael R Bristow, Luisa Mestroni and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Thomas G MartinDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, 80303, USA.
Dakota R HuntBioFrontiers Institute, University of Colorado Boulder, Boulder CO, 80303, USA.
Christopher C EbmeierDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, 80303, USA.
Abhishek P DhandDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christina AlamanaDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, 80303, USA.
Joseph C ClevelandDepartment of Surgery, Division of Cardiothoracic Surgery, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Sharon L GrawAdult Medical Genetics Program, Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Sarah BrunerAdult Medical Genetics Program, Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Michael R BristowCardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Luisa MestroniAdult Medical Genetics Program, Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Matthew R G TaylorAdult Medical Genetics Program, Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Jason A BurdickBioFrontiers Institute, University of Colorado Boulder, Boulder CO, 80303, USA.
Amrut V AmbardekarCardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Peter M ButtrickCardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Leslie A LeinwandDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, 80303, USA.ORCID 0000-0003-1470-4810

Funding

Colorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · NCATS · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS, RONALD J. SOKOL · 2023 to 2026
$30.7M
MYOSIN GENE DIVERSITY AND FUNCTIONR01GM029090 · NIGMS · YESHIVA UNIVERSITY · PI Leslie Anne Leinwand · 1985 to 2026
$12.3M
Cardiomyocyte phenotype and mechanotransduction in Filamin C gene variants causing arrhythmogenic cardiomyopathyR01HL147064 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MESTRONI, LUISA, TAYLOR, MATTHEW R · 2020 to 2023
$2.1M
The role of FOXO1 in the development and regression of cardiac hypertrophyF32HL170637 · NHLBI · UNIVERSITY OF COLORADO · PI MARTIN, THOMAS GWYNN · 2023 to 2024
$96k
NCATS NIH HHS UM1 TR004399NHLBI NIH HHS F32 HL170637NHLBI NIH HHS R01 HL147064NIGMS NIH HHS R01 GM029090
6 · The paper itself

Abstract

Restoration of cardiac function in patients with advanced heart failure is rare, and the molecular processes that regulate recovery are unknown. To identify potential mechanisms, we studied paired myocardial samples before and after left ventricular assist device therapy, where significant cardiac functional recovery occurred in ~25% of patients. We found that expression of the nuclear B isoform of Ca

Identifiers

PMID40475607
PMCPMC12139807

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.