Evidence map›Paper›PMID 40475604›Full record

ArticlebioRxiv : the preprint server for biology2025

Stimulant medications affect arousal and reward, not attention.

Benjamin P Kay, Muriah D Wheelock, Joshua S Siegel, Ryan Raut, Roselyne J Chauvin, Athanasia Metoki, Aishwarya Rajesh, Andrew Eck, Jim Pollaro, Anxu Wang and 26 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors.

Benjamin P KayDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-3628-8029
Muriah D WheelockMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Joshua S SiegelDepartment of Psychiatry, New York University Langone Center for Psychedelic Medicine, New York, NY, USA.
Ryan RautMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Roselyne J ChauvinDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-5786-4705
Athanasia MetokiDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Aishwarya RajeshMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Andrew EckMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Jim PollaroMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Anxu WangDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Vahdeta SuljicDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Babatunde AdeyemoDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Noah J BadenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Kristen M ScheidterDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Julia MonkDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Nadeshka Ramirez-PerezDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Samuel R KrimmelDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Russel T ShinoharaPenn Statistics in Imaging and Visualization Center, Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Brenden Tervo-ClemmensDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Robert J M HermosilloMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Steven M NelsonMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Timothy J HendricksonMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Thomas MadisonMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Lucille A MooreMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Óscar Miranda-DomínguezMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Anita RandolphMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Eric FeczkoMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID 0000-0003-1337-5517
Jarod L RolandDepartment of Neurosurgery, Washington University School of Medicine, St Louis, MO, USA.
Ginger E NicolDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Timothy O LaumannDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Scott MarekDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Evan M GordonMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Marcus E RaichleDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-0032-9052
Deanna M BarchDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Damien A FairMasonic Institute for the Developing Brain, University of Minnesota Medical School, Minneapolis, MN, USA.
Nico U F DosenbachDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

Funding

ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
Child Neurologist Career Development Program (CNCDP)K12NS098482 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCHLAGGAR, BRADLEY L · 2016 to 2025
$26.2M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
Adolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5M
NIBIB NIH HHS K99 EB029343NIBIB NIH HHS R00 EB029343NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIH HHS S10 OD025200NIH HHS S10 OD030477NIMH NIH HHS K99 MH121518NIMH NIH HHS R00 MH121518NIMH NIH HHS R00 MH129616NIMH NIH HHS R01 MH096773NIMH NIH HHS R01 MH115357NIMH NIH HHS R01 MH129493NIMH NIH HHS R44 MH121276NIMH NIH HHS R44 MH122066NIMH NIH HHS R44 MH124567NINDS NIH HHS K12 NS098482NINDS NIH HHS K23 NS088590NINDS NIH HHS K23 NS123345NINDS NIH HHS R44 NS129521
6 · The paper itself

Abstract

Prescription stimulants such as methylphenidate are being used by an increasing portion of the population, primarily children. These potent norepinephrine and dopamine reuptake inhibitors promote wakefulness, suppress appetite, enhance physical performance, and are purported to increase attentional abilities. Prior functional magnetic resonance imaging (fMRI) studies have yielded conflicting results about the effects of stimulants on the brain's attention, action/motor, and salience regions that are difficult to reconcile with their proposed attentional effects. Here, we utilized resting-state fMRI (rs-fMRI) data from the large Adolescent Brain Cognitive Development (ABCD) Study to understand the effects of stimulants on brain functional connectivity (FC) in children (

Identifiers

PMID40475604
PMCPMC12139890

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.