Evidence map›Paper›PMID 40475553›Full record

ArticlebioRxiv : the preprint server for biology2025

AMPA receptor activation within the prelimbic cortex is necessary for incubated cocaine-craving.

Laura L Huerta Sanchez, Mirette G Tadros, Hoa H T Doan, Sylvie V Vo, Sanil R Chaudhari, Taylor L Li, Peter B James, Audrey Y Na, Fernando J Cano, Tod E Kippin and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Laura L Huerta SanchezDepartmnet of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.ORCID 0009-0001-0870-8252
Mirette G TadrosDepartmnet of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.
Hoa H T DoanDepartmnet of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.
Sylvie V VoDepartmnet of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.
Sanil R ChaudhariDepartmnet of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.
Taylor L LiDepartmnet of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.
Peter B JamesDepartmnet of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.
Audrey Y NaDepartmnet of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.
Fernando J CanoDepartmnet of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.
Tod E KippinDepartmnet of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.
Karen SzumlinskiDepartmnet of Psychological and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, USA.

Funding

Incubated drug-craving and neurochemical interactionsR01DA053328 · NIDA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SZUMLINSKI, KAREN KATHLEEN · 2021 to 2025
$1.8M
Role of PL CaMKII in incubated cocaine-cravingF99NS141388 · NINDS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI HUERTA SANCHEZ, LAURA · 2024 to 2024
$43k
NIDA NIH HHS R01 DA053328NINDS NIH HHS F99 NS141388
6 · The paper itself

Abstract

The incubation of craving is a behavioral phenomenon in which cue-elicited craving increases during a period of drug abstinence. Incubated cocaine-craving is associated with increased extracellular glutamate within the medial prefrontal cortex (mPFC) and this release, particularly within the prelimbic (PL) subregion, is necessary for incubated cocaine-craving. A potential candidate mediating these incubation-driving effects of glutamate release within the PL are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). To investigate the role of mPFC AMPARs in incubated craving, male and female Sprague-Dawley rats were trained to self-administer cocaine for 6 h/day for 10 consecutive days. Either during early or later withdrawal, rats were infused intra-PL with the AMPAR antagonist NBQX (0 or 1 μg/0.5 μl per side), followed by 30-min tests for cue-reinforced responding. Immunoblotting was also conducted to relate the expression of incubated cocaine- and sucrose-craving to AMPAR subunit expression within mPFC subregions. Intra-PL NBQX blocked incubated craving expressed in late, but not early, withdrawal. No incubation-related changes in AMPAR subunit expression were detected within the PL or IL of rats of either sex and no estrus-associated changes in subunit expression were detected in female rats exhibiting incubated cocaine-craving. In contrast, elevated GluA1 expression was observed within the IL of male rats exhibiting an incubation of sucrose-craving. Together, these findings indicate a necessary role for AMPARs within the PL in driving incubated cocaine-craving and suggest that AMPARs located within the IL may be involved also in sucrose-craving selectively in males.

Indexed as

AMPA receptorsdrug cravingincubation of drug cravingincubation of sucrose cravingprefrontal cortex

Identifiers

PMID40475553
PMCPMC12139874

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.