Evidence map›Paper›PMID 40475546›Full record

ArticlebioRxiv : the preprint server for biology2025

Genetic crosses reveal genomic loci responsible for virulence in

Sebastian Shaw, Xue Li, Gracyn Buenconsejo, Tiffany H Zhou, Allison Cohen, Daniel Yasur-Landau, Rui Xiao, Daniel P Beiting, Timothy J C Anderson, Boris Striepen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Sebastian ShawDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-7163-5650
Xue LiTexas Biomedical Research Institute, San Antonio, Texas, USA.
Gracyn BuenconsejoDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Tiffany H ZhouDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0009-0004-8695-9243
Allison CohenDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1692-2443
Daniel Yasur-LandauDivision of Parasitology, Kimron Veterinary Institute, Bet Dagan, Israel.
Rui XiaoDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4178-3497
Daniel P BeitingDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Timothy J C AndersonTexas Biomedical Research Institute, San Antonio, Texas, USA.ORCID 0000-0002-0191-0204
Boris StriepenDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-7426-432X

Funding

Systems genetics of artemisinin resistanceP01AI127338 · NIAID · UNIVERSITY OF NOTRE DAME · PI Stefan HI Kappe · 2017 to 2026
$21.3M
MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUMR01AI048071 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Tim J Anderson · 2000 to 2026
$8.4M
Immunity to CryptosporidiumR01AI148249 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHRISTOPHER A HUNTER, BORIS STRIEPEN · 2020 to 2026
$5.3M
Genetic Analysis of CryptosporidiumR01AI112427 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STRIEPEN, BORIS · 2014 to 2023
$4.2M
Sexual Development of CryptosporidiumR01AI127798 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STRIEPEN, BORIS · 2017 to 2025
$4.1M
Interrogating the molecular architecture of the Cryptosporidium host-parasite interfaceF32AI183654 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Allison Cohen · 2024 to 2026
$231k
NIAID NIH HHS F32 AI183654NIAID NIH HHS P01 AI127338NIAID NIH HHS R01 AI048071NIAID NIH HHS R01 AI112427NIAID NIH HHS R01 AI127798NIAID NIH HHS R01 AI148249
6 · The paper itself

Abstract

The relationship between parasite genotype and pathogenesis is largely unknown for

Identifiers

PMID40475546
PMCPMC12139775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.