Evidence map›Paper›PMID 40475519›Full record

ArticlebioRxiv : the preprint server for biology2025

Cellular and Immune Adaptations at the Maternal-Fetal Interface in Bats.

Allyson Caldwell, Liheng Yang, Rebecca L Casazza, Rizban E Worota, Cole McCutcheon, Patrick S Creisher, Erika Zhan, Clara Reasoner, Ashley Higgins, Tony Schountz and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Rebecca L CasazzaORCID 0000-0002-8271-6947
Rizban E Worota
Patrick S CreisherORCID 0000-0001-6828-3455
Erika Zhan

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bats maintain pregnancy despite extended gestation relative to other small mammals, high fetal investment, recurrent pathogen exposure, and the metabolic demands of flight. These physiological extremes likely drive unique adaptations in placental function and maternal-fetal immune regulation, yet the cellular and molecular basis of these adaptations remains largely unknown. Here, we mapped the cellular landscape of the Jamaican fruit bat ( Abstract Figure: Summary: Pregnancy in bats occurs under a combination of physiological stressors rarely encountered in other mammals, including extended gestation relative to other small mammals, elevated metabolic load, temperature fluctuations associated with flight, and constant microbial exposure. To investigate how the placenta adapts to these challenges, we profiled Jamaican fruit bat ( Highlights: Single-nucleus RNA-seq defines cell types and differentiation pathways in the bat placenta Bat trophoblast and decidua gland organoids recapitulate

Identifiers

PMID40475519
PMCPMC12139947

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.