Evidence map›Paper›PMID 40475492›Full record

ArticlebioRxiv : the preprint server for biology2025

Bacteria detect neutrophils via a system that responds to hypochlorous acid and flow.

Ilona P Foik, Runhang Shu, Serena Abbondante, Summer J Kasallis, Lauren A Urban, Andy P Huang, Leora Duong, Michaela E Marshall, Eric Pearlman, Timothy L Downing and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ilona P FoikDepartment of Physics & Astronomy, University of California Irvine, USA.ORCID 0000-0002-5927-5776
Runhang ShuDepartment of Molecular Biology & Biochemistry, University of California Irvine, USA.
Serena AbbondanteDepartment of Ophthalmology, University of California Irvine, USA.
Summer J KasallisDepartment of Physics & Astronomy, University of California Irvine, USA.ORCID 0000-0003-0975-5840
Lauren A UrbanDepartment of Microbiology & Molecular Genetics, University of California Irvine, USA.ORCID 0000-0001-5606-7712
Andy P HuangSchool of Biological Sciences, University of California Irvine, USA.
Leora DuongDepartment of Molecular Biology & Biochemistry, University of California Irvine, USA.
Michaela E MarshallDepartment of Ophthalmology, University of California Irvine, USA.ORCID 0000-0001-9381-780X
Eric PearlmanDepartment of Ophthalmology, University of California Irvine, USA.ORCID 0000-0003-0137-7582
Timothy L DowningDepartment of Microbiology & Molecular Genetics, University of California Irvine, USA.ORCID 0000-0002-5197-3684
Albert SiryapornDepartment of Physics & Astronomy, University of California Irvine, USA.ORCID 0000-0002-2056-9937

Funding

Spatial epigenomics: A new framework for overcoming mechanical heterogeneity in solid tumorsDP2CA250382 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI DOWNING, TIMOTHY LAMONT · 2019 to 2019
$2.4M
Epigenetic regulation of macrophage response to biomaterial implantsR21EB027840 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DOWNING, TIMOTHY LAMONT, LIU, WENDY · 2019 to 2020
$398k
NCI NIH HHS DP2 CA250382NIBIB NIH HHS R21 EB027840
6 · The paper itself

Abstract

Neutrophils respond to the presence of bacteria by producing oxidative molecules that are lethal to bacteria, including hypochlorous acid (HOCl). However, the extent to which bacteria detect activated neutrophils or the HOCl that neutrophils produce, has not been understood. Here we report that the opportunistic bacterial pathogen

Indexed as

hypochlorous acidneutrophilsoxidative stressP. aeruginosashear sensing

Identifiers

PMID40475492
PMCPMC12139993

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.