Evidence map›Paper›PMID 40475440›Full record

ArticlebioRxiv : the preprint server for biology2025

Perivascular space mediated the interaction between sleep, and brain functional connectivity in the healthy aging population.

Nien-Chu Shih, Joey Contreras, Wendy J Mack, Jeiran Choupan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Nien-Chu ShihLaboratory of Neuro Imaging, USC Mark and Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-9490-4323
Joey ContrerasAlzheimer's Disease Cooperative Study (ADCS), University of California San Diego, La Jolla, CA, USA.
Wendy J MackDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jeiran ChoupanLaboratory of Neuro Imaging, USC Mark and Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Funding

MAPPING THE HUMAN CONNECTOME DURING TYPICAL AGINGU01AG052564 · NIA · WASHINGTON UNIVERSITY · PI SALAT, DAVID H, TERPSTRA, MELISSA J · 2016 to 2020
$18.9M
Structural and diffusion changes of perivascular space in aging, cognitive decline and Alzheimer's diseaseR01AG070825 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHOUPAN, JEIRAN · 2021 to 2025
$4.1M
Mapping human brain perivascular space in lifespan using human connectome project dataRF1MH123223 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHOUPAN, JEIRAN · 2020 to 2020
$1.3M
NIA NIH HHS R01 AG070825NIA NIH HHS U01 AG052564NIMH NIH HHS RF1 MH123223
6 · The paper itself

Abstract

Perivascular space (PVS) surrounds the perforating arteries or draining veins of the cerebral cortex as part of the brain clearance system. Previous studies showed that sleep affects both brain clearance function and brain functional connectivity (FC). However, the impact of PVS characteristics on brain FC remains unclear. This study investigated these associations and their link to cognition. We utilized cross-sectional structural MRI and resting state-fMRI data from 512 health aging population in the HCP-Aging dataset, together with Pittsburgh Sleep Ǫuality Index questionnaire and NIH cognitive tests. Our results showed that basal ganglia (BG)-PVS volume fraction (VF) was positively correlated with FC in the right anterior medial temporal gyrus (aMTG) and right temporal regions, while centrum-semiovale (CSO)-PVS VF was positively correlated with FC in the left hippocampus and right frontal regions. Increased CSO-PVS VF in early middle-aged adults showed higher hippocampal FC and better cognitive performance. Interestingly, individuals with longer time spent in bed had larger BG-PVS VF linked to higher FC in the right aMTG. Additionally, older adults with better sleep quality had larger BG-PVS VF linked to higher FC in the right aMTG. These findings suggest that PVS morphology may reflect changes in neural connections involved in memory-related regions.

Indexed as

CognitionFunctional connectivityMagnetic resonance imagingPerivascular spaceSleep

Identifiers

PMID40475440
PMCPMC12139948

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.