Evidence map›Paper›PMID 40475432›Full record

ArticlebioRxiv : the preprint server for biology2025

Ancient convergence with prokaryote defense and recent adaptations to lentiviruses in primates characterize the ancestral immune factors SAMD9s.

Alexandre Legrand, Rémi Demeure, Amandine Chantharath, Carine Rey, Julie Baltenneck, Cameron L M Gilchrist, Joana L Rocha, Clara Loyer, Léa Picard, Andrea Cimarelli and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Alexandre LegrandCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, UCBL1, CNRS UMR5308, ENS de Lyon, Université de Lyon, Lyon, France.
Rémi DemeureCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, UCBL1, CNRS UMR5308, ENS de Lyon, Université de Lyon, Lyon, France.
Amandine ChantharathCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, UCBL1, CNRS UMR5308, ENS de Lyon, Université de Lyon, Lyon, France.
Carine ReyCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, UCBL1, CNRS UMR5308, ENS de Lyon, Université de Lyon, Lyon, France.
Julie BaltenneckCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, UCBL1, CNRS UMR5308, ENS de Lyon, Université de Lyon, Lyon, France.
Cameron L M GilchristSchool of Biological Sciences, Seoul National University, Seoul, South Korea.
Joana L RochaDepartment of Integrative Biology, University of California, Berkeley, California, USA.
Clara LoyerCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, UCBL1, CNRS UMR5308, ENS de Lyon, Université de Lyon, Lyon, France.
Léa PicardCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, UCBL1, CNRS UMR5308, ENS de Lyon, Université de Lyon, Lyon, France.
Andrea CimarelliCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, UCBL1, CNRS UMR5308, ENS de Lyon, Université de Lyon, Lyon, France.
Martin SteineggerSchool of Biological Sciences, Seoul National University, Seoul, South Korea.ORCID 0000-0001-8781-9753
Francois RoussetCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, UCBL1, CNRS UMR5308, ENS de Lyon, Université de Lyon, Lyon, France.
Peter H SudmantDepartment of Integrative Biology, University of California, Berkeley, California, USA.ORCID 0000-0002-9573-8248
Lucie EtienneCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, UCBL1, CNRS UMR5308, ENS de Lyon, Université de Lyon, Lyon, France.ORCID 0000-0002-8585-7534

Funding

The evolution and diversity of mutation, molecular fidelity, and genome structureR35GM142916 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Peter Heshedahl Sudmant · 2021 to 2026
$2.5M
NIGMS NIH HHS R35 GM142916
6 · The paper itself

Abstract

Human

Indexed as

antiviral factorComparative genomicscomparative immunologyconservationconvergencediversificationevolutionHIVinnate immunitylentivirusSAMD9SAMD9Lshared / ancestral immunitystructural similarity

Identifiers

PMID40475432
PMCPMC12139748

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.