Evidence map›Paper›PMID 40475422›Full record

ArticlebioRxiv : the preprint server for biology2025

Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation.

Youssef E Sibih, Abraham O Dada, Emily Cunningham, Niels Olshausen, Jasleen Kaur, Velmurugan Jayabal, Sena Oten, Sanjeev Herr, Cesar Nava Gonzales, Andy Daniel and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Youssef E SibihDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0839-5428
Abraham O DadaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Emily CunninghamDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Niels OlshausenDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Jasleen KaurDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Velmurugan JayabalDepartment of Radiology, University of California, San Francisco, San Francisco, CA, USA.
Sena OtenDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Sanjeev HerrDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Cesar Nava GonzalesDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Andy DanielDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Saritha KrishnaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Vardhaan S AmbatiDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Alexander A AabediDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Gray UmbachDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Kanish MirchiaDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Poortata LalwaniDepartment of Neurobiology and Behavior, Department of Cognitive Sciences, University of California, Irvine, Irvine, CA, USA.
Edward F ChangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
David R RaleighDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Srikantan NagarajanDepartment of Radiology, University of California, San Francisco, San Francisco, CA, USA.
David BrangDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Shawn L Hervey-JumperDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-4699-260X

Funding

Portable TMS-EEG device for bedside detection of covert consciousnessR41NS137850 · NINDS · INTRINSIC POWERS, INC. · PI Melanie Boly · 2025 to 2026
$992k
NINDS NIH HHS R41 NS137850
6 · The paper itself

Abstract

Diffuse gliomas remodel neuronal circuits with prognostic and therapeutic significance for patients. Electrophysiologic measures of cortical excitability hold promise for monitoring disease progression and evaluating therapeutic responses. The power law exponent (aperiodic slope) reflects the balance between excitatory and inhibitory activity within neuronal networks, a critical aspect of normal brain function often disrupted in neurological conditions. Despite its potential, the significance of the aperiodic slope in glioma-infiltrated tissue and its underlying cellular processes has not been fully investigated. Here, we integrate multimodal electrophysiological analysis with transcriptomic profiling to analyze the aperiodic slope in both normal and glioma-infiltrated cortex. We determine that glioma infiltration induces a flattening of the aperiodic slope, indicating a shift toward excitation dominance that varies according to tumor subtype and correlates with impairments in semantic naming. Single-nucleus RNA sequencing revealed that cortical regions with flat aperiodic slope exhibit transcriptional programs enriched in glutamatergic signaling, membrane depolarization, and excitatory synaptic transmission. The aperiodic slope responds to pharmacologically induced changes in cortical inhibition during propofol administration, a GABA

Indexed as

Aperiodic slopeexcitation-inhibition balanceglioblastomagliomaisocitrate dehydrogenase mutant gliomasnRNA-seqtranscriptomics

Identifiers

PMID40475422
PMCPMC12139770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.