ArticleActa ortopedica brasileira2025
30 YEARS OF BONE GIANT CELL TUMOR IN THE KNEE: A BRAZILIAN PERSPECTIVE.
Article in Acta ortopedica brasileira, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To analyze the evolution of patient/tumor characteristics and treatments for GCTB in the knee in Brazil over 30 years and assess changes in local recurrence rates. Methods: Retrospective study of 335 patients (1989-2021) from 16 Brazilian centers. Data on patient/tumor characteristics, recurrence, metastasis, and treatment trends were evaluated. Results: Campanacci grade 3 tumors, pulmonary metastasis, and local recurrence rates were 56.7%, 5.3%, and 15.8%, respectively. Recurrence was 21.4% for curettage and 9% for resection. Curettage with denosumab showed 23.8% recurrence, versus 21% for curettage alone. Overall, local recurrence decreased from 22.9% (1989-2005) to 15.1% (2006-2021), with a significant drop after en bloc resection (23% to 7.8%), while curettage-related recurrence remained stable. Conclusions: Despite an increase in aggressive tumors, local recurrence decreased, especially after en bloc resection. These findings emphasize the challenges of managing rare diseases in emerging economies.
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