Evidence map›Paper›PMID 40475258›Full record

ArticleiScience2025

The HDL-transporting scavenger receptor B1 promotes viral infection through endolysosomal acidification.

Jill McConnell, Sun-Young Lim, Thomas Cicuto, Ping Liu, Pyae Phyo Kyawe, Manish Kandpal, Evan S Bradley, Kendi Okuda, Neal Silverman, Jennifer P Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jill McConnellDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Sun-Young LimDepartment of Medicine, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Thomas CicutoDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Ping LiuDepartment of Medicine, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Pyae Phyo KyaweDepartment of Medicine, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Manish KandpalDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Evan S BradleyDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Kendi OkudaDepartment of Medicine, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Neal SilvermanDepartment of Medicine, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Jennifer P WangDepartment of Medicine, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
William M McDougallDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, 364 Plantation Street, Worcester, MA 01605, USA.

Funding

From Drosophila Immunity to Anti-InflammatoriesR01AI060025 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Neal Silverman · 2004 to 2026
$9.4M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
NIAID NIH HHS R01 AI060025NIAID NIH HHS T32 AI095213
6 · The paper itself

Abstract

Virus infections pose a continuous threat to human health and can result in millions of deaths per year. SARS-CoV-2 infection has been linked to the high-affinity high-density lipoprotein (HDL) receptor scavenger receptor class B, type 1 (SR-B1). Mechanisms by which SR-B1 supports SARS-CoV-2 infection and replication, as well as the breadth of viruses that exploit this receptor, are incompletely defined. In evaluating the role of SR-B1 in the biology of infection with SARS-CoV-2, influenza A virus, and vesicular stomatitis virus, we show that SR-B1 chemical inhibition or knockout adversely affects infection for these viruses. Inhibiting SR-B1 results in lack of acidification in the endolysosomal compartment and entrapment of SARS-CoV-2 in endosomal-lysosomal vesicles. These findings together indicate that SR-B1, and possibly HDL, is critical for successful SARS-CoV-2 trafficking through a pH-dependent vesicular entry pathway. Our work provides insights into how SR-B1 can impact viral infection in human lung cells.

Indexed as

BiochemistryBiological sciencesCell biologyMicrobiologyNatural sciencesViral microbiologyVirology

Identifiers

PMID40475258
PMCPMC12138404

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.