Evidence map›Paper›PMID 40475147›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Understanding the Epidemiology of Malaria in Zanzibar through Molecular and Serological Analysis of Samples collected during Reactive Case Detection.

Varun Goel, Wahida Hassan, Caroline Murphy, Barbara B Choloi, Mohamed Ali, Bakari Mohamed, Abdallah Zacharia, Msolo C Dominick, Kyaw Thwai, Safia Mohammed and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Varun GoelDepartment of Geography, University of South Carolina, Columbia, SC 29208.ORCID 0000-0002-2933-427X
Wahida HassanZanzibar Malaria Elimination Program (ZAMEP), Zanzibar, Tanzania.ORCID 0009-0004-0452-751X
Caroline MurphyDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 27599 USA.
Barbara B CholoiDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA.
Mohamed AliZanzibar Malaria Elimination Program (ZAMEP), Zanzibar, Tanzania.ORCID 0000-0002-7330-7340
Bakari MohamedZanzibar Malaria Elimination Program (ZAMEP), Zanzibar, Tanzania.ORCID 0000-0003-3976-7965
Abdallah ZachariaDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Msolo C DominickDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Kyaw ThwaiDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA.
Safia MohammedZanzibar Malaria Elimination Program (ZAMEP), Zanzibar, Tanzania.
Shija J ShijaZanzibar Malaria Elimination Program (ZAMEP), Zanzibar, Tanzania.
Jeffrey A BaileyDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, 02912 USA.ORCID 0000-0002-6899-8204
Anders BjörkmanDepartment of Global Public Health, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-8882-130X
Billy E NgasalaDepartment of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0001-9300-7719
Eric RogierDivision of Digestive Disease and Nutrition, University of Kentucky, Lexington, Kentucky 40506.
Jonathan J JulianoDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 27599 USA.ORCID 0000-0002-0591-0850
Jessica T LinDivision of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599 USA.ORCID 0000-0002-4516-723X

Funding

Importation and transmission of malaria in Zanzibar: a case study for eliminationR01AI155730 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, JONATHAN J, LIN, JESSICA · 2021 to 2024
$2.8M
Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
NIAID NIH HHS K24 AI134990NIAID NIH HHS R01 AI155730
6 · The paper itself

Abstract

Background: The Zanzibar archipelago has been a pre-elimination region for malaria thanks to rigorous control interventions, but recent surges in malaria cases have been observed. The contribution of non-falciparum species to the current malaria situation is unknown. Methods: This study investigates the seroepidemiology of falciparum and non-falciparum malaria species in Zanzibar. Leveraging plasma extracted from dried blood spots (DBS) collected during reactive case detection (RCD) activities across Unguja island from May 2022 to May 2023, we measured immunoglobulin G (IgG) responses to Results: Out of 1,618 participants surveyed in 35 RCDs, 35.3% had exposure to any malaria species, with Discussion: This study suggests a significant contribution of non-falciparum species to the local epidemiology in Zanzibar. Current control and elimination efforts, focused on

Indexed as

malariamolecular epidemiologyserologyTanzaniaZanzibar

Identifiers

PMID40475147
PMCPMC12140523

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.