Evidence map›Paper›PMID 40475139›Full record

ArticlemedRxiv : the preprint server for health sciences2025

A multi-omics resource of B cell activation reveals genetic mechanisms for immune-mediated diseases.

Vitor R C Aguiar, Marcella E Franco, Nada Abdel Aziz, Daniela Fernandez-Salinas, Marcos Chiñas, Mariasilvia Colantuoni, Qian Xiao, Nicolaj Hackert, Yifei Liao, Rodrigo Cervantes-Diaz and 29 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Vitor R C AguiarDivision of Immunology, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0002-4137-9518
Marcella E FrancoDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Nada Abdel AzizDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Daniela Fernandez-SalinasDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Marcos ChiñasDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Mariasilvia ColantuoniDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Qian XiaoDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Nicolaj HackertDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Yifei LiaoDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital.
Rodrigo Cervantes-DiazDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Marc ToddDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Brian WaufordDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Alex WactorDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Vaishali PrahaladDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Raquel Laza-BriviescaDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Roxane DarboussetDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Qiang WangDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Scott JenksDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University.
Kevin S CashmanDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University.
Esther ZumaqueroDepartment of Microbiology, University of Alabama at Birmingham.
Zhu ZhuCenter for Cellular Profiling, Brigham and Women's Hospital, Harvard Medical School.
Junning CaseCenter for Cellular Profiling, Brigham and Women's Hospital, Harvard Medical School.
Paloma CejasCenter for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School.
Miguel GomezCenter for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School.
Hannah AinsworthDepartment of Biostatistics and Data Science, Wake Forest School of Medicine.
Miranda MarionDepartment of Biostatistics and Data Science, Wake Forest School of Medicine.
Mehdi BenamarDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Pui LeeDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Lauren HendersonDivision of Immunology, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0003-0242-4029
Margaret ChangDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Kevin WeiCenter for Cellular Profiling, Brigham and Women's Hospital, Harvard Medical School.
Henry LongCenter for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School.ORCID 0000-0001-6849-6629
Carl D LangefeldDepartment of Biostatistics and Data Science, Wake Forest School of Medicine.
Benjamin E GewurzDivision of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital.
Ignacio SanzDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University.
Jeffrey A SparksDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School.ORCID 0000-0002-5556-4618
Esra MeidanDivision of Immunology, Boston Children's Hospital, Harvard Medical School.
Peter A NigrovicDivision of Immunology, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0002-2126-3702
Maria Gutierrez-ArcelusDivision of Immunology, Boston Children's Hospital, Harvard Medical School.ORCID 0000-0001-7898-7691

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Program Project in the Genetics of SLEP01AR049084 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2002 to 2012
$12.7M
VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel Hal Solomon · 2017 to 2026
$9.8M
SequencingP01AI083194 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI KIMBERLY, ROBERT P. · 2009 to 2013
$9.6M
Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
Ly6 family members in neutrophil biologyR01AR065538 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2014 to 2024
$4.0M
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung DiseaseR01AR077607 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SPARKS, JEFFREY ANDREW · 2021 to 2025
$3.7M
Rheumatoid Arthritis-associated Parenchymal Lung Disease: Clinical and Molecular PhenotypesR01HL155522 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Jeffrey Andrew Sparks, George R Washko · 2022 to 2026
$3.5M
Bridging the gap between GWAS and mechanism in JIAR01AR073201 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic · 2019 to 2026
$3.2M
Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic DiseasesR01AR080659 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Jeffrey Andrew Sparks · 2023 to 2026
$2.9M
T resident memory cells in arthritisR01AR075906 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2019 to 2023
$2.1M
NCATS NIH HHS UL1 TR002541NHLBI NIH HHS R01 HL155522NIAID NIH HHS P01 AI083194NIAMS NIH HHS P01 AR049084NIAMS NIH HHS P30 AR070253NIAMS NIH HHS P30 AR072577NIAMS NIH HHS R01 AR065538NIAMS NIH HHS R01 AR073201NIAMS NIH HHS R01 AR075906NIAMS NIH HHS R01 AR077607NIAMS NIH HHS R01 AR080659
6 · The paper itself

Abstract

Most genetic variants that confer risk of complex immune-mediated diseases (IMDs) affect gene regulation in specific cell types. Their target genes and focus cell types are often unknown, partially because some effects are hidden in untested cell states. B cells play central roles in IMDs, including autoimmune, allergic, infectious, and cancer-related diseases. Despite this established importance, B cell activation states are underrepresented in functional genomics studies. In this study, we obtained B cells from 26 healthy female donors and stimulated them

Identifiers

PMID40475139
PMCPMC12140513

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.