ArticleAmerican journal of ophthalmology case reports2025
Histopathological changes in the trabecular meshwork in primary congenital glaucoma.
Article in American journal of ophthalmology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To evaluate the morphological changes in the ex-vivo trabecular meshwork TM specimens from patients with primary congenital glaucoma. Methods: Five trabecular meshwork (TM) specimens obtained after microincisional trabeculectomy from 4 patients with primary congenital glaucoma (mean age) were analyzed using Results: The trabecular meshwork in PCG showed an expansion of the juxtacanalicular and corneoscleral meshwork regions with increased cellularity, thickened TM beams, prominent spindle-shaped nuclei suggesting epithelial mesenchymal transformation predominantly and two morphologically distinct zones of the juxtacanalicular region. Conclusions: Increased cellularity, zonal expansion and mesenchymal changes in specific TM regions suggest aberrant differentiation and differential dysgenesis of different TM regions in PCG.
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