Evidence map›Paper›PMID 40475126›Full record

ArticleAmerican journal of ophthalmology case reports2025

Spontaneously resolved invasive conjunctival squamous cell carcinoma with anterior chamber invasion in low-grade lymphoma patient.

Tanya Boghosian, Promporn Patarajierapun, Ben J Glasgow, Carla B Berkowitz, Clemence Bonnet, Tara A McCannel, Brad D Barrows, Simon S M Fung

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PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tanya BoghosianStein Eye Institute, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Promporn PatarajierapunStein Eye Institute, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Ben J GlasgowStein Eye Institute, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Carla B BerkowitzStein Eye Institute, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Clemence BonnetStein Eye Institute, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Tara A McCannelStein Eye Institute, University of California Los Angeles, Los Angeles, CA, 90095, United States.
Brad D BarrowsCommunity Memorial Health System, Ventura, CA, 93003, United States.
Simon S M FungStein Eye Institute, University of California Los Angeles, Los Angeles, CA, 90095, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To report a case of invasive conjunctival squamous cell carcinoma (SCC) with anterior chamber invasion that resolved spontaneously after incisional biopsy and anterior chamber paracentesis in the absence of any treatment. Observations: A 76-year-old man presented with a 3-month history of a recurrent mass in the right eye. Examination showed an elevated, smooth amorphous lesion at the nasal conjunctivae, adherent to the scleral surface. There was also a pseudohypopyon at the angle adjacent to the lesion. Incisional biopsy of the right conjunctival lesion and intracameral fine-needle aspiration (FNA) were performed, which confirmed recurrent invasive SCC. Brachytherapy was planned but was deferred when spontaneous regression of the lesion was noted at the interim visit. The lesion completely resolved within one year post-biopsy with no additional interventions and has remained with no signs of recurrence two years after regression, permitting uneventful cataract surgery for visual rehabilitation. Conclusions and Importance: Invasive conjunctival squamous cell carcinoma is an advanced form of ocular surface neoplasia, typically necessitating extensive surgical excision and chemical or biologic therapy. This case highlights a potential pathway for the spontaneous resolution of squamous cell carcinoma post-incisional biopsy, although the precise underlying mechanisms remain unclear. Understanding these mechanisms could inform future treatment for squamous cell carcinoma and other neoplasms.

Indexed as

Invasive conjunctival squamous cell carcinomaOcular surface squamous neoplasiaSpontaneous regression

Identifiers

PMID40475126
PMCPMC12139222

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.