Fermented ginseng powder enriched with rare ginsenosides ameliorates high-fat diet-induced obesity by modulating adipogenesis and inflammation.

Xueyue Tai, Jiating Li, Jianwei Song, Bao Zhong, Fenglin Li

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Article in Food & nutrition research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Xueyue Tai *College of Food Science and Nutritional Engineering, Jilin Agriculture Science and Technology University, Jilin, China.

Jiating Li *School of Public Health, Jilin Medical University, Jilin, China.

Jianwei SongCollege of Food Science and Nutritional Engineering, Jilin Agriculture Science and Technology University, Jilin, China.

Bao ZhongCollege of Food Science and Nutritional Engineering, Jilin Agriculture Science and Technology University, Jilin, China.

Fenglin LiCollege of Food Science and Nutritional Engineering, Jilin Agriculture Science and Technology University, Jilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Administration of high-dose fermented ginseng powder (2.385 mg/g) resulted in a reduction in body weight and an improvement in blood biochemical parameters in high-fat diet (HFD)-fed mice. Significant reductions in lipid droplet size were observed in both liver and epididymal adipose tissues. Western blot analysis showed increased protein levels of PPAR-α, PPAR-γ, and PGC-1 in the HFD + low-dose lyophilized fermented ginseng powder (HDL), HFD + medium-dose lyophilized fermented ginseng powder (HDM), and HFD + high-dose lyophilized fermented ginseng powder (HDH) groups compared to the HD group. Furthermore, the phosphorylation of AMPK (P-AMPK) and ACC (P-ACC) was significantly elevated. Conversely, western blot analysis demonstrated a decrease in the expression of inflammatory cytokines IL-1, IL-6, and TNF-α in the CG, HDL, HDM, and HDH groups compared to the HD group. Gene expression analysis revealed a downregulation of lipid anabolism-related genes, including

Indexed as

fermented ginsenghigh-fat dietlipid-loweringmodulating effectobesity

Identifiers

PMID40475063

DOI10.29219/fnr.v69.12230

PMCPMC12138988

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