Evidence map›Paper›PMID 40475017›Full record

ArticleFrontiers in oncology2025

CD46 TREM1 regulates the autophagy marker LC3B ATG5 in oral squamous cell carcinoma.

Xiaodan Liu, Fumin Zheng, Meihua Gao, Yuanfei Wang, Xiaofang Lv, Beibei Cong, Wanchun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaodan Liu *School of Stomatology, Binzhou Medical University, Yantai, China.
Fumin Zheng *Department of Oral Mucosal Diseases, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, China.
Meihua GaoDepartment of Oral Mucosal Diseases, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, China.
Yuanfei WangDepartment of Oral Mucosal Diseases, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, China.
Xiaofang LvDepartment of Oral Mucosal Diseases, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, China.
Beibei CongDepartment of Oral Mucosal Diseases, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, China.
Wanchun WangDepartment of Oral Mucosal Diseases, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aims to explore the regulatory effect of abnormal expression of CD46 and TREM1 on LC3B and ATG5 and to provide new targets for the molecular mechanism and treatment of OSCC. Methods: Human oral squamous cell carcinoma cells CAL-27 were selected for Results: Conclusion: OSCC cells have high expression of CD46 and TREM1, while low expression of LC3B and ATG5, and the autophagy apoptosis signal is weakened. Interfering with CD46 can up-regulate the expression of autophagy apoptosis genes, reduce the tumor inflammatory microenvironment, induce the apoptosis of OSCC cells, and inhibit the proliferation and metastasis of OSCC. This study provides a new idea for the mechanism and targeted therapy of OSCC and has important theoretical significance and clinical application value.

Indexed as

ATG5CD46/TREM1LC3Bregulation mechanismsquamous cell carcinoma

Identifiers

PMID40475017
PMCPMC12137063

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.