ArticleFrontiers in pharmacology2025
Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Multi-omics analysis of untargeted metabolomics and gut microbiota study on the mechanism of Astragalus-Safflower to coordinate the regulation of energy metabolism pathways and gut microbiota remodeling to improve ischemic stroke.Metabolic brain disease · 2026Article
- Gut microbiota-mediated neuroinflammation following stroke: mechanisms and intervention strategies.Journal of translational medicine · 2026Review
- Plant Polysaccharides in Alzheimer's Disease: From Phytochemistry to Microbiota-Gut-Brain Axis Mechanisms-Resolving the Pharmacokinetic-Pharmacodynamic Paradox.Molecules (Basel, Switzerland) · 2026Review
- MiR-124 alleviates cerebral ischemia-reperfusion injury by targeting SLC1A5 to inhibit neuronal ferroptosis.Iranian journal of basic medical sciences · 2026Article
- Exploring common circulating diagnostic biomarkers for sleep disorders and stroke based on machine learning.Frontiers in neurology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Ischemic stroke (IS) is the most common type of stroke, known for its high rates of morbidity, disability, mortality, and recurrence. Polygoni Multiflori Radix Praeparata (PM), a traditional Chinese medicinal tonic, is frequently used for treating IS. Its polysaccharides (PMP) are acknowledged for their hepatoprotective, immunomodulatory, and neuroprotective properties. However, the effectiveness and mechanisms of PMP remain inadequately understood. This study seeks to evaluate the impact of PMP on IS and clarify the potential mechanisms involved. Methods: PMP was obtained by water extraction, alcohol precipitation, Sevage deproteinization, and dialysis. Its molecular weight, monosaccharide composition, and FT-IR spectrum were characterized. IS was established by middle cerebral artery occlusion/reperfusion (MCAO/R) in male SD rats. Neurological assessment, histopathology, and protein factors detection assessed PMP's effectiveness. Further, Results: PMP significantly improved the neurologic functions and reduced the cerebral infarction volume in MCAO/R rats. Cerebral ischemia/reperfusion (I/R) injured brain and also affected intestine, leading to gut barrier disruption. PMP could lower the levels of inflammatory cytokines, such as TNF-α and IL-1β, and boost tight junction protein both in brain and intestinal tissues. Metabolomic analysis shows PMP raised intestinal levels of SCFAs (butyrate, propionate) and beneficial amino acids, thus improving disrupted carbohydrate and amino acid metabolism. 16S rRNA gene sequencing revealed that the abundance of Conclusion: PMP markedly enhanced SCFAs and amino acid metabolism, as well as the proliferation of beneficial gut microbiota, thereby promoting intestinal health and barrier integrity, and thus relieving MCAO/R induced I/R injury both in brain and intestine. Our study substantiates the potential of PMP as a prebiotic health supplement in clinical settings for the prevention and treatment of IS.
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