Evidence map›Paper›PMID 40474940›Full record

ArticleInternational journal of particle therapy2025

First Clinical Implementation of Step-and-Shoot Proton Arc Therapy for Head and Neck Cancer Treatment.

Peilin Liu, Xiaoda Cong, Jian Liang, Xiangkun Xu, Weili Zheng, Craig Stevens, Rohan Deraniyagala, Xiaoqiang Li, Xuanfeng Ding

Abstract read
In one paragraph

Article in International journal of particle therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peilin LiuDepartment of Radiation Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
Xiaoda CongDepartment of Radiation Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
Jian LiangDepartment of Radiation Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
Xiangkun XuDepartment of Radiation Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
Weili ZhengDepartment of Radiation Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
Craig StevensDepartment of Radiation Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
Rohan DeraniyagalaDepartment of Radiation Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
Xiaoqiang LiDepartment of Radiation Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.
Xuanfeng DingDepartment of Radiation Oncology, Corewell Health William Beaumont University Hospital, Royal Oak, MI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Dynamic Spot-scanning Proton Arc (SPArc Patients and Methods: An in-house spot and energy-layer sparsity optimization algorithm was integrated into a clinical treatment planning system. The algorithm prioritized higher MU-weighted energy layers and spots to ensure delivery efficiency and superior plan quality while meeting machine requirements (≥0.02MU/spot). A Dynamic SPArc simulator calculated delivery times, and a machine-learning-based synthetic CT(synCT) platform monitored dose robustness. In June 2024, a head-neck cancer patient with parotid gland malignancy was treated using SPArc Results: SPArc Conclusion: The SPArc

Indexed as

Adaptive planningNeck-neck cancerStep-and-shoot proton arc therapy

Identifiers

PMID40474940
PMCPMC12138570

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.