ArticleJournal of biomedical optics2025
Terahertz Mie scattering in tissue: diffuse polarimetric imaging and Monte Carlo validation in highly attenuating media models.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Optimized Calibration of Terahertz Polarimetric Imaging Systems With Imperfect Polarizers for Accurate Jones-Matrix Mapping.Research square · 2026Article
- In Situ Calibration of Terahertz Time-Domain Polarimetry Systems with a Leaky Wire Grid Polarizer.Research square · 2026Article
- Implanted Miniature Light Devices for Phototherapeutics.Advanced therapeutics · 2026Article
- Synergistic terahertz platforms for precision oncology.Theranostics · 2026Review
- A Universal Approach to Mie Scatter Correction in FTIR Analysis of Microsized Samples.ACS omega · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Significance: Changes in the structure of tissue occur in many disease processes, such as the boundaries of cancerous tumors and burn injuries. Spectroscopic and polarimetric alterations of terahertz light caused by Mie scattering patterns have the potential to be a diagnostic marker. Aim: We present an analysis of Monte Carlo simulation of Mie scattering of polarized terahertz light from cancerous tumor budding, compare the simulation with experimental results obtained in phantom models, and present an analysis of a polarization-sensitive terahertz scan of an Approach: Using a Monte Carlo simulation, we modeled the changes in diffuse intensity and degree of polarization of broadband off-specular terahertz light due to scattering particles in highly attenuating tissue. We extracted the Mueller matrix of the tissue using this model and analyzed the Lu-Chipman product decomposition matrices. We compared this model with experimental data from four phantoms consisting of polypropylene particles of varying sizes embedded in gelatin. Finally, we induced a full-thickness burn injury in Results: Simulation revealed contrast in the Stokes vectors and Mueller Matrix elements for varying scattering particle sizes. Experimental phantom results showed contrast between different sizes of scattering particles in degree of polarization and diffuse intensity in agreement with Monte Carlo simulation results. Finally, we demonstrated a similar diffused imaging signal contrast between burned and healthy regions of Conclusion: Polarimetric terahertz imaging has the potential to detect structural changes due to biological disease processes.
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Registered trials
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