Evidence map›Paper›PMID 40474715›Full record

ArticlePathologica2025

Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusion: report of two cases with different clinical presentation.

Elisabetta Merenda, Katia Paciaroni, Emilia Scalzulli, Massimo Breccia, Stefano Licci, Luisa Bizzoni, Carla Giordano, Emma Rullo

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In one paragraph

Article in Pathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Elisabetta MerendaDepartment of Radiologic, Oncologic and Pathologic Sciences, Sapienza University of Rome, Italy.
Katia PaciaroniHematology Unit, San Filippo Hospital, Rome Italy.
Emilia ScalzulliDepartment of Cellular Biotechnology and Hematology BCE, Sapienza University of Rome, Italy.
Massimo BrecciaDepartment of Cellular Biotechnology and Hematology BCE, Sapienza University of Rome, Italy.
Stefano LicciPathology Unit, San Filippo Hospital, Rome Italy.
Luisa BizzoniDepartment of Translational and Precision Medicine, Sapienza University of Rome, Italy.
Carla GiordanoDepartment of Radiologic, Oncologic and Pathologic Sciences, Sapienza University of Rome, Italy.
Emma RulloDepartment of Radiologic, Oncologic and Pathologic Sciences, Sapienza University of Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (M/LN-eo-TK) such as PDGFRA, PDGFRB, FGFR1, JAK2, FLT3 rearrangement and ETV6::ABL1 fusion include rare and heterogeneous clinical-pathological entities with some similarities, not always associated with peripheral eosinophilia. Accurate diagnosis and demonstration of the specific genetic substrate have important implications since target therapy is possibly available. Herein we report two cases showing different bone marrow features and clinical presentation. Recognition of eosinophilic granuloblasts prompted genetic analysis that showed PDGFRB (case 1) and PDGFRA (case 2) gene rearrangement. Diagnosis of M/LN-eo-TK may be challenging. Pathologists may be the first professionals to suspect the disorder and should be aware of the therapeutic implication. Accurate BOM marrow evaluation with a panel of immunohistochemical reactions, and specific molecular analyses are required for proper diagnosis.

Indexed as

EosinophiliaGene FusionMyeloproliferative DisordersOncogene Proteins, FusionProtein-Tyrosine KinasesGene RearrangementHumansReceptor, Platelet-Derived Growth Factor alphaReceptor, Platelet-Derived Growth Factor betaOncogene Proteins, FusionPDGFRB protein, humanProtein-Tyrosine KinasesReceptor, Platelet-Derived Growth Factor alphaReceptor, Platelet-Derived Growth Factor betaHypereosinophiliaMyeloid/lymphoid neoplasmsPDGFRAPDGFRBTKI

Identifiers

PMID40474715
PMCPMC12142289

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