Evidence map›Paper›PMID 40474708›Full record

ReviewPathologica2025

Head and neck hematolymphoid proliferations: what is new?

Silvia Varricchio, Rosaria Cappiello, Francesca Magnoli, Daniela Russo, Giovanna Motta, Clara Bertuzzi, Elena Sabattini, Gennaro Ilardi, Mariarosaria Cervasio, Claudia Giordano and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Silvia VarricchioDepartment of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy.
Rosaria CappielloDepartment of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy.
Francesca MagnoliUnit of Oral Medicine and Pathology, Dental Clinic, Azienda Socio-Sanitaria Territoriale dei Sette Laghi, Varese, Italy.
Daniela RussoDepartment of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy.
Giovanna MottaHaematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Clara BertuzziHaematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Elena SabattiniHaematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Gennaro IlardiDepartment of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy.
Mariarosaria CervasioDepartment of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy.
Claudia GiordanoDepartment of Clinical Medicine and Surgery, Hematology Section, University of Naples Federico II, Naples, Italy.
Alessandro SeverinoDepartment of Clinical Medicine and Surgery, Hematology Section, University of Naples Federico II, Naples, Italy.
Marco PicardiDepartment of Clinical Medicine and Surgery, Hematology Section, University of Naples Federico II, Naples, Italy.
Massimo MascoloDepartment of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2024, the World Health Organization published its 5th edition of tumor classification, which comprises several updates and modifications in the "blue book" focused on head and neck tumors. These changes feature a systematized and expanded discussion on haematolymphoid proliferations using a multi-parameter approach that comprises clinical features, morphology, immunophenotype, and genetic data, with the latter becoming an essential characteristic for classification. Moreover, for the first time, the World Health Organization has included non-neoplastic diseases, such as reactive lymphoid proliferations, alongside several recognized independent disorders, including Epstein-Barr Virus positive mucocutaneous ulcers and IgG4-related diseases. Also, various neoplastic diseases, such as paediatric-type follicular lymphoma and large B-cell lymphoma with IRF4 rearrangement, are recognized as independent entities. Finally, the focus has expanded to include different types of histiocytic neoplasms. This review examines and illustrates the main changes and updates on hematolymphoid proliferation and neoplasia in the Head and Neck chapter of the 5th Edition of the Head and Neck WHO classification.

Indexed as

Head and Neck NeoplasmsHumansWorld Health Organizationhead and neckhematolymphoid proliferations and non-neoplastic conditionsWorld Health Organization

Identifiers

PMID40474708
PMCPMC12142295

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.