Evidence map›Paper›PMID 40474658›Full record

Trial reportOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2025

Efficacy of patching combined with action video games in amblyopic children aged 4-10 years: A randomised clinical trial.

Laura Asensio-Jurado, Marc Argilés, Valldeflors Vinuela-Navarro, Lluïsa Quevedo-Junyent, Dennis M Levi

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Efficacy of patching combined with action video games in amblyopic children aged 4-10 years: A randomised clinical trial.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura Asensio-JuradoCentre for Sensors, Instruments and Systems Development (CD6), Terrassa, Spain.ORCID https://orcid.org/0000-0001-9890-5577
Marc ArgilésCentre for Sensors, Instruments and Systems Development (CD6), Terrassa, Spain.ORCID https://orcid.org/0000-0001-5474-9832
Valldeflors Vinuela-NavarroCentre for Sensors, Instruments and Systems Development (CD6), Terrassa, Spain.ORCID https://orcid.org/0000-0002-1933-5906
Lluïsa Quevedo-JunyentSchool of Optics and Optometry, Universitat Politècnica de Catalunya, Terrassa, Spain.ORCID https://orcid.org/0000-0002-0976-9372
Dennis M LeviHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, Berkeley, California, USA.ORCID https://orcid.org/0000-0002-5350-8639

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the impact of using child-friendly action video games combined with monocular occlusion for the treatment of children with amblyopia compared with occlusion alone.

methodsTwenty-eight children aged 4-10 years (mean age: 5.80 ± 1.54 years) with anisometropic and/or strabismic amblyopia were included. Each participant was previously prescribed an optimal refractive correction, and after 8 weeks was randomly assigned to one of the treatment groups: action video games (AVG) plus occlusion (n = 14) or passive occlusion alone (PO) (n = 14). Visual acuity (VA) and stereoacuity (ST) were measured at baseline and following 14, 28 and 42 h of treatment. Compliance was monitored using parental registry and Google Analytics.

resultsAfter 42 h, both groups showed significant improvement in the visual acuity of the amblyopic eye, p < 0.001 and p = 0.04 for the AVG and PO groups, respectively. However, VA recovery was significantly greater (p = 0.01) and faster with monocular AVG plus occlusion (0.18 logMAR) compared with occlusion alone (0.06 logMAR) in the amblyopic eye. The small improvement (0.02 logMAR) in the non-amblyopic eye was not significant for either group. No significant differences between groups were observed for ST (p = 0.38).

conclusionsThese findings suggest that combining occlusion and action video games at home results in greater effectiveness and efficiency in improving VA in children with anisometropic and strabismic amblyopia.

Indexed as

AmblyopiaSensory DeprivationVideo GamesVision, BinocularVisual AcuityChildChild, PreschoolDepth PerceptionFemaleFollow-Up StudiesHumansMaleTreatment Outcomeaction video gameamblyopiaanisometropiaocclusionstrabismus

Identifiers

PMID40474658
PMCPMC12357224

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.