Evidence map›Paper›PMID 40474569›Full record

ArticleMovement disorders clinical practice2025

Sustained Therapeutic Benefits Using Image-Guided Programming at Activation of Deep Brain Stimulation for Parkinson's Disease.

Jason L Aldred, Theresa Zesiewicz, Michael S Okun, Adolfo Ramirez-Zamora, Okeanis E Vaou, Leo Verhagen Metman, Corneliu C Luca, Ritesh Ramdhani, Jennifer Durphy, Yarema B Bezchlibnyk and 11 more

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Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jason L AldredSelkirk Neurology, Spokane, Washington, USA.ORCID https://orcid.org/0000-0001-7441-0967
Theresa ZesiewiczDepartment of Neurology and Neurosurgery, University of South Florida, Tampa, Florida, USA.
Michael S OkunNorman Fixel Institute for Neurological Diseases, Department of Neurology, University of Florida, Gainesville, Florida, USA.
Adolfo Ramirez-ZamoraNorman Fixel Institute for Neurological Diseases, Department of Neurology, University of Florida, Gainesville, Florida, USA.
Okeanis E VaouDepartment of Neurology and Neurosurgery, University of Texas San Antonio, San Antonio, Texas, USA.
Leo Verhagen MetmanDepartment of Neurology, Northwestern University School of Medicine, Chicago, Illinois, USA.
Corneliu C LucaDepartment of Neurology and Neurosurgery, University of Miami School of Medicine, Miami, Florida, USA.
Ritesh RamdhaniDepartment of Neurology, Zucker School of Medicine at Hofstra/Northwell Health, Hempstead, New York, USA.
Jennifer DurphyDepartment of Neurology and Neurosurgery, Albany Medical Center, Albany, New York, USA.
Yarema B BezchlibnykDepartment of Neurology and Neurosurgery, University of South Florida, Tampa, Florida, USA.
Jonathan D CarlsonInland Neurosurgery and Spine, Spokane, Washington, USA.
Kelly D FooteNorman Fixel Institute for Neurological Diseases, Department of Neurology, University of Florida, Gainesville, Florida, USA.
Sepher B SaniDepartment of Neurosurgery, Rush University Medical Center, Chicago, Illinois, USA.
Alexander M PapanastassiouDepartment of Neurology and Neurosurgery, University of Texas San Antonio, San Antonio, Texas, USA.
Jonathan R JagidDepartment of Neurology and Neurosurgery, University of Miami School of Medicine, Miami, Florida, USA.
David B WeintraubDepartment of Neurosciences, Nassau University Medical Center, East Meadow, New York, USA.
Julie PilitsisDepartment of Neurosurgery, University of Arizona College of Medicine, Tucson, Arizona, USA.
Andres HurtadoBoston Scientific Neuromodulation, Valencia, California, USA.
Rajat S ShivacharanBoston Scientific Neuromodulation, Valencia, California, USA.ORCID https://orcid.org/0000-0001-6824-4368
Benjamin ReeseBoston Scientific Neuromodulation, Valencia, California, USA.
Edward GoldbergBoston Scientific Neuromodulation, Valencia, California, USA.

Funding

Boston Scientific Corporation
6 · The paper itself

Abstract

backgroundThe efficacy of deep brain stimulation (DBS) for Parkinson's disease (PD) depends on optimizing stimulation parameters for each patient, a time-sensitive process. Image-guided programming (IGP) offers a promising method to streamline this.

objectiveThe objective was to evaluate the real-world effectiveness of an IGP tool with directional leads during the initial programming of bilateral subthalamic nucleus (STN) or globus pallidus internus (GPi) DBS in PD patients.

methodsA total of 57 PD patients (46 bilateral STN, 11 bilateral GPi) from the Vercise DBS Registry (NCT#02071134) were enrolled into the GUIDE XT substudy. Time for initial programming using IGP, Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III at baseline, 6-months, and 1-year postactivation, Global Impression of Change from patients and clinicians, and the continued use of IGP-suggested settings were analyzed. Stimulation field model (SFM) overlap between initial and 1-year target volumes was also examined.

resultsMotor function significantly improved at 6 months and 1 year (55% and 45%, P < 0.0001) compared to baseline, as assessed by MDS-UPDRS III (Meds OFF/Stim ON). Initial programming sessions of bilateral leads using IGP (n = 56) lasted 39.4 ± 4.4 minutes (mean ± standard error [SE]), whereas it was completed in less than 30 minutes in 55% of subjects. Contact selection, polarity, and fractionalization determined at initial programing using IGP remained unchanged in 52% and 43% of subjects (n = 21) up to 6 months and 1 year, respectively. The average SFM overlap for all subjects was 92% (SE: 15%) at the 1-year visit.

conclusionsIGP facilitates efficient initial programming sessions, providing stable settings that result in long-term motor improvements.

Indexed as

Deep Brain StimulationParkinson DiseaseAgedFemaleGlobus PallidusHumansMaleMiddle AgedRegistriesSubthalamic NucleusTreatment OutcomeDBSGPiimage‐guided programmingParkinson's diseaseSTN

Identifiers

PMID40474569
PMCPMC12625106

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.