Evidence map›Paper›PMID 40474381›Full record

ArticleJournal of clinical periodontology2025

Effect of Tooth Splinting on Clinical Outcomes following Periodontal Regenerative Therapy in Teeth with Mobility Degree 1 or 0: A Propensity Score-Matched Analysis.

Risako Mikami, Miho Ishimaru, Koji Mizutani, Hidehiro Shioyama, Takanori Matsuura, Norio Aoyama, Tomonari Suda, Yukako Kusunoki, Kohei Takeda, Tatsuhiko Anzai and 6 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Risako MikamiDepartment of Advanced Biomaterials, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID 0000-0003-1398-0450
Miho IshimaruDepartment of Dental Public Health, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Koji MizutaniDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID 0000-0002-1610-7430
Hidehiro ShioyamaDepartment of Lifetime Oral Health Care Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Takanori MatsuuraDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID 0000-0001-7539-1227
Norio AoyamaDepartment of Education Planning, Kanagawa Dental University, Yokosuka, Kanagawa, Japan.ORCID 0000-0002-8498-4494
Tomonari SudaDepartment of Oral Surgery, Secomedic Hospital, Funabashi, Chiba, Japan.
Yukako KusunokiGraduate School of Medical and Dental Sciences, Behavioral Dentistry, Institute of Science Tokyo, Tokyo, Japan.
Kohei TakedaHigashi Sakura Dental Clinic, Nagoya, Aichi, Japan.ORCID 0000-0002-9063-2532
Tatsuhiko AnzaiDepartment of Biostatistics, M&D Data Science Center, Institute of Science Tokyo, Tokyo, Japan.
Kunihiko TakahashiDepartment of Biostatistics, M&D Data Science Center, Institute of Science Tokyo, Tokyo, Japan.
Koichiro MatsuoDepartment of Oral Health Sciences for Community Welfare, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Jun AidaDepartment of Dental Public Health, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID 0000-0002-8405-9872
Yuichi IzumiDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID 0000-0003-2623-8255
Akira AokiDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID 0000-0001-5936-1116
Takanori IwataDepartment of Periodontology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID 0000-0002-5461-7298

Funding

Ministry of Education, Culture, Sports, Science and Technology 23K16014
6 · The paper itself

Abstract

aimThe evidence for tooth splinting during periodontal regenerative therapy is limited. We aimed to investigate the adjunctive benefits of tooth splinting on clinical outcomes. MATERIALS AND

methodsIn total, 194 intrabony defects in 126 participants were prospectively evaluated over three years following periodontal regenerative therapy with an enamel matrix derivative. Clinical attachment level (CAL), probing depth (PD) and radiographic bone defect depth (RBD) were assessed. Propensity score matching (PSM) was employed to assign surgical sites to splinting and non-splinting groups, and multilevel regression was used to analyse the impact of tooth splinting on clinical outcomes.

resultsUsing PSM, 37 sites each from 32 and 30 participants in the splinting and non-splinting groups, respectively, were matched using the propensity score. Both groups included 26 and 11 sites with tooth mobility degrees 0 and 1, respectively. Significant improvements in CAL, PD and RBD were observed in both groups compared to baseline over the 3-year period. However, there were no significant differences among these parameters between the groups at the 1- and 3-year follow-ups.

conclusionNo statistically significant adjunctive benefits of tooth splinting were observed in this study. However, further research with a larger sample size may be required to detect smaller but potentially clinically relevant effects.

Indexed as

Guided Tissue Regeneration, PeriodontalTooth MobilityAdultAgedAlveolar Bone LossDental Enamel ProteinsFemaleFollow-Up StudiesHumansMaleMiddle AgedPeriodontal Attachment LossPeriodontal PocketPropensity ScoreProspective StudiesTreatment OutcomeDental Enamel Proteinsenamel matrix proteinsenamel matrix derivativeperiodontal regenerative therapypropensity scoretooth splinting

Identifiers

PMID40474381
PMCPMC12377938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.