ArticleJournal of nanobiotechnology2025
An ultra-sensitive and point-of-care time-resolved fluorescence immunochromatographic platform for trace-level brucellosis antibody rapid on-site detection.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiology of Brucellosis Among Deer in China From 1978 to 2025: A Systematic Review and Meta-Analysis.Transboundary and emerging diseases · 2026Pooled it
- Advances in rapid detection technologies for zoonotic diseases: a one health-oriented review.Frontiers in cellular and infection microbiology · 2026Review
- Innovations, Applications, and Future Trends in Veterinary Diagnostic Technologies.Transboundary and emerging diseases · 2026Review
- Development of a dual fluorescent microsphere-based lateral flow immunoassays for simultaneous detection ofFrontiers in veterinary science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Brucellosis, a significant zoonotic disease, poses a threat to the animal husbandry industry as well as human health. To facilitate rapid and highly sensitive on-site brucellosis diagnostics, we have devised a time-resolved fluorescence immunochromatographic test strip (TRFICTS). TRFICTS employs time-resolved fluorescent microspheres (TRFMs) as both signal amplifiers and label reporters, achieving a sensitivity that is at least 12,800 times greater than the rose Bengal plate test (RBT) recommended by the World Organization for Animal Health (WOAH). TRFICTS reaches a trace-level sensitivity with a detection limit of 0.048 IU/mL, making it suitable for detecting trace antibodies produced during the early stages of brucellosis infection. Furthermore, TRFICTS allows for detection at room temperature using 30 min through simple procedures, and a portable TRFICTS reader has been developed to automate the quantification of fluorescence signals for brucellosis diagnostics. Proven through practical applications, TRFICTS demonstrates high sensitivity, specificity, accuracy, and repeatability. Therefore, TRFICTS represents a promising tool for epidemiologic surveillance and brucellosis management.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.