ArticleJournal of medical case reports2025
Transient islet-antigen 2 positivity at diagnosis of diabetes during COVID-19 infection in an adolescent with a NEUROD1 variant: a case report.
Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased incidence of type 1 and type 2 diabetes has been reported in association with the coronavirus disease 2019 pandemic. Little is known about the impact of coronavirus disease 2019 on the presentation of monogenic forms of diabetes. This case report describes diagnosis of the uncommon maturity onset diabetes of the young (neurogenic differentiation factor 1-maturity-onset diabetes of the young) after transient autoimmunity during coronavirus disease 2019 infection. CASE PRESENTATION: A 19-year-old Mexican male with autism spectrum disorder was diagnosed with diabetes without ketoacidosis during metabolic screening laboratory testing. He tested positive for coronavirus disease 2019 with no respiratory symptoms. His hemoglobin A1c was 14.2%, and had elevated islet-antigen 2 antibody. His blood glucose responded rapidly to initial dietary reduction in carbohydrate intake without insulin initiation, with subsequent improvement in hemoglobin A1c to 7.4% 2 months later. Then, 2 years after diagnosis, his hemoglobin A1c was 6.0%, and repeat antibody testing was negative. He was taking lisinopril for microalbuminuria, but required no medications for glucose control. Genetic testing identified a variant of NEUROD1 c.514C > T, p.(Leu172Phe). His mother who was subsequently diagnosed with diabetes, underwent targeted variant testing and was found to have the same neurogenic differentiation factor 1 variant.
conclusionsCoronavirus disease 2019 possibly triggered transient autoimmunity, leading to the diagnosis of neurogenic differentiation factor 1-maturity-onset diabetes of the young diabetes. This is also the first description of the clinical features associated with this particular neurogenic differentiation factor 1 variant.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.