Evidence map›Paper›PMID 40474234›Full record

ReviewEuropean journal of medical research2025

Recent developments in the research of Stevens-Johnson syndrome and toxic epidermal necrolysis: pathogenesis, diagnosis and treatment.

Li-Min Yao, Xia Su, Li-Ling Liu, Yan-Ning Qi, Bo Wei, Ran Ma, Xiao-Qing Du

Abstract readReview
In one paragraph

Review in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Li-Min YaoDepartment of Dermatology and Venereology, Bethune International Peace Hospital, No. 398 of Zhongshan West Road, Qiaoxi District, Shijiazhuang, 050200, China.
Xia SuDepartment of Dermatology and Venereology, Bethune International Peace Hospital, No. 398 of Zhongshan West Road, Qiaoxi District, Shijiazhuang, 050200, China.
Li-Ling LiuDepartment of Dermatology and Venereology, Bethune International Peace Hospital, No. 398 of Zhongshan West Road, Qiaoxi District, Shijiazhuang, 050200, China.
Yan-Ning QiDepartment of Dermatology and Venereology, Bethune International Peace Hospital, No. 398 of Zhongshan West Road, Qiaoxi District, Shijiazhuang, 050200, China.
Bo WeiDepartment of Dermatology and Venereology, Bethune International Peace Hospital, No. 398 of Zhongshan West Road, Qiaoxi District, Shijiazhuang, 050200, China.
Ran MaDepartment of Dermatology and Venereology, Bethune International Peace Hospital, No. 398 of Zhongshan West Road, Qiaoxi District, Shijiazhuang, 050200, China.
Xiao-Qing DuDepartment of Dermatology and Venereology, Bethune International Peace Hospital, No. 398 of Zhongshan West Road, Qiaoxi District, Shijiazhuang, 050200, China. duxiaoqingdxq@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe disorders affecting the skin and mucous membranes, identified by low incidence but high mortality rates. Medications, particularly antibiotics, are the most common causative agents, and infection is also considered a common pathogenic factor. Multiple alleles diagnosed with drug allergies, which can help in predicting the occurrence of SJS and TEN were detected during research. Although the pathogenesis of SJS and TEN is not yet fully understood, the current gold standard for treatment involves early diagnosis and treatment, discontinuation of the allergenic drugs, and supportive care. Treatment options include systemic use of corticosteroids, intravenous immunoglobulin, cyclosporine A, plasmapheresis, and TNF-α inhibitors.

Indexed as

Stevens-Johnson SyndromeHumansBiomarkersPathogenesisSeverityStevens-Johnson syndromeToxic epidermal necrolysisTreatment

Identifiers

PMID40474234
PMCPMC12139062

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.